Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium
dc.contributor.author | Hannon, Tamara S. | |
dc.contributor.author | Kahn, Steven E. | |
dc.contributor.author | Utschneider, Kristina M. | |
dc.contributor.author | Buchanan, Thomas A. | |
dc.contributor.author | Nadeau, Kristen J. | |
dc.contributor.author | Zeitler, Philip S. | |
dc.contributor.author | Ehrmann, David A. | |
dc.contributor.author | Arslanian, Silva S. | |
dc.contributor.author | Caprio, Sonia | |
dc.contributor.author | Edelstein, Sharon L. | |
dc.contributor.author | Savage, Peter J. | |
dc.contributor.author | Mather, Kieren J. | |
dc.contributor.department | Department of Pediatrics, IU School of Medicine | en_US |
dc.date.accessioned | 2017-08-02T14:10:17Z | |
dc.date.available | 2017-08-02T14:10:17Z | |
dc.date.issued | 2017 | |
dc.description.abstract | The Restoring Insulin Secretion (RISE) study was initiated to evaluate interventions to slow or reverse the progression of β-cell failure in type 2 diabetes (T2D). To design the RISE study, we undertook an evaluation of methods for measurement of β-cell function and changes in β-cell function in response to interventions. In the present paper, we review approaches for measurement of β-cell function, focusing on methodologic and feasibility considerations. Methodologic considerations included: (1) the utility of each technique for evaluating key aspects of β-cell function (first- and second-phase insulin secretion, maximum insulin secretion, glucose sensitivity, incretin effects) and (2) tactics for incorporating a measurement of insulin sensitivity in order to adjust insulin secretion measures for insulin sensitivity appropriately. Of particular concern were the capacity to measure β-cell function accurately in those with poor function, as is seen in established T2D, and the capacity of each method for demonstrating treatment-induced changes in β-cell function. Feasibility considerations included: staff burden, including time and required methodological expertise; participant burden, including time and number of study visits; and ease of standardizing methods across a multicentre consortium. After this evaluation, we selected a 2-day measurement procedure, combining a 3-hour 75-g oral glucose tolerance test and a 2-stage hyperglycaemic clamp procedure, augmented with arginine. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Hannon, T., Kahn, S., Utschneider, K., Bucahan, T., Nadeau, K., Zeitler, P., Ehrmann, D., Arslanian, S., Caprio, S., Edelstein, S., Savage, P., Mather, K. and for the RISE Consortium (2017), A Review of Methods for Measuring β-Cell Function: Design Considerations from the Restoring Insulin Secretion (RISE) Consortium. Diabetes, Obesity, and Metabolism. Accepted Author Manuscript. doi:10.1111/dom.13005 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/13697 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1111/dom.13005 | en_US |
dc.relation.journal | Diabetes, Obesity, and Metabolism | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | Restoring Insulin Secretion (RISE) study | en_US |
dc.subject | type 2 diabetes | en_US |
dc.subject | β-cell failure | en_US |
dc.title | Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium | en_US |
dc.type | Article | en_US |