A community-based approach to cervical cancer prevention in western Kenya: An AMPATH feasibility project

dc.contributor.authorOrang’o, Omenge
dc.contributor.authorTonui, Philip
dc.contributor.authorMuthoka, Kapten
dc.contributor.authorKiptoo, Stephen
dc.contributor.authorMaina, Titus
dc.contributor.authorAgosa, Mercy
dc.contributor.authorErmel, Aaron
dc.contributor.authorTong, Yan
dc.contributor.authorBrown, Darron
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-06-21T13:06:11Z
dc.date.available2023-06-21T13:06:11Z
dc.date.issued2022-05-23
dc.description.abstractObjectives: Centralized programs have been ineffective in reducing the burden of cervical cancer among Kenyan women. A community-based pilot study was initiated to screen Kenyan women for cervical cancer and to vaccinate their children against human papillomavirus (HPV). Methods: Women were educated about cervical cancer prevention at community meetings. Women then provided self-collected vaginal swabs for oncogenic HPV testing using the Roche Cobas Assay. All women were then referred to the local clinic for Visual Inspection with Acetic Acid (VIA). Women were offered the quadrivalent HPV vaccine for their children if and when it became available for the study. Results: Women in western Kenya were invited to participate in community meetings. A total of 200 women were enrolled: 151 (75.5%) were HIV-uninfected and 49 (24.5%) were HIV-infected; the median age for all women was 42 years. High-risk (HR)-HPV types were detected in 49 of swabs from all 200 participants (24.5%) including 20.5% of HIV-uninfected women and 36.7% of HIV-infected women (P = .022). VIA was performed on 198 women: 192 had normal examinations and six had abnormal examinations. Five cervical biopsies revealed two cases of CIN 2 and one CIN 3. Although all mothers were willing to have their children (N = 432) vaccinated, the HPV vaccine could not be delivered to Kenya during the study period. Conclusions: Kenyan women were willing to attend community meetings to learn about prevention of cervical cancer, to provide self-collected vaginal swabs for HPV testing, to travel to the Webuye Clinic for VIA following the collection of swabs, and to have their children vaccinated against HPV. HR-HPV was prevalent, especially in HIV-infected women. As a result of this pilot study, this community-based strategy to prevent cervical cancer will be continued in western Kenya.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationOrang'o O, Tonui P, Muthoka K, et al. A community-based approach to cervical cancer prevention in western Kenya: An AMPATH feasibility project. SAGE Open Med. 2022;10:20503121221102111. Published 2022 May 23. doi:10.1177/20503121221102111en_US
dc.identifier.urihttps://hdl.handle.net/1805/33892
dc.language.isoen_USen_US
dc.publisherSageen_US
dc.relation.isversionof10.1177/20503121221102111en_US
dc.relation.journalSAGE Open Medicineen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourcePMCen_US
dc.subjectCervical cancer screeningen_US
dc.subjectSelf-collected vaginal swabsen_US
dc.subjectKenyaen_US
dc.subjectHIVen_US
dc.titleA community-based approach to cervical cancer prevention in western Kenya: An AMPATH feasibility projecten_US
dc.typeArticleen_US
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