Predictors of depression outcomes in adults with cancer: A 12 month longitudinal study

dc.contributor.authorCohee, Andrea A.
dc.contributor.authorKroenke, Kurt
dc.contributor.authorVachon, Eric
dc.contributor.authorWu, Jingwei
dc.contributor.authorTu, Wanzhu
dc.contributor.authorJohns, Shelley A.
dc.date.accessioned2021-10-04T21:04:36Z
dc.date.available2021-10-04T21:04:36Z
dc.date.issued2020
dc.description.abstractThe prevalence of depression in patients with cancer ranges from 8% to 24% within the first year of receiving a cancer diagnosis. Identifying predictors of depression outcomes may facilitate tailored or more intensive treatment in patient subgroups with a poorer prognosis for depression improvement. The objective of this study was to determine predictors of depression severity and improvement over 12 months among adults with cancer. Methods Longitudinal analysis of data from the Indiana Cancer Pain and Depression trial was performed in 309 patients (n = 309) with cancer-related depression. Depression outcomes were assessed at baseline, 1, 3, 6, and 12 months and included depression severity (Hopkins Symptom Checklist-20) and global improvement (Depression Global Rating of Improvement (DGRI)). Multivariable repeated measures analyses, adjusting for treatment group, baseline depression, and time point, were conducted to determine symptom (pain), demographic, and clinical predictors of depression outcomes over 12 months. Results Pain was particularly important, with a clinically meaningful reduction in pain predicting a 12–24% greater odds of depression global improvement. Other factors that independently predicted better depression outcomes over 12 months included female sex, newly-diagnosed or maintainence/disease-free cancer, fewer comorbid medical conditions, and higher socioeconomic status. As expected, the three covariates adjusted for in the model (treatment group, passage of time, and baseline depression severity) also predicted depression outcomes. Conclusion Pain as well as several demographic and clinical factors predict depression outcomes over 12 months. These findings may help identify patient subgroups requiring closer monitoring and more intensive or tailored depression treatment.en_US
dc.identifier.citationCohee, A. A., Kroenke, K., Vachon, E., Wu, J., Tu, W., & Johns, S. A. (2020). Predictors of depression outcomes in adults with cancer: A 12 month longitudinal study. Journal of psychosomatic research, 136, 110169.en_US
dc.identifier.urihttps://hdl.handle.net/1805/26687
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof:10.1016/j.jpsychores.2020.110169en_US
dc.subjectCanceren_US
dc.subjectDepressionen_US
dc.subjectPainen_US
dc.subjectRandomized controlled trialen_US
dc.subjectPrognosisen_US
dc.titlePredictors of depression outcomes in adults with cancer: A 12 month longitudinal studyen_US
dc.typeArticleen_US
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