Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs

dc.contributor.authorPuls, Theodore J.
dc.contributor.authorFisher, Carla S.
dc.contributor.authorCox, Abigail
dc.contributor.authorPlantenga, Jeannie M.
dc.contributor.authorMcBride, Emma L.
dc.contributor.authorAnderson, Jennifer L.
dc.contributor.authorGoergen, Craig J.
dc.contributor.authorBible, Melissa
dc.contributor.authorMoller, Tracy
dc.contributor.authorVoytik‑Harbin, Sherry L.
dc.contributor.departmentSurgery, School of Medicineen_US
dc.date.accessioned2022-05-23T19:35:41Z
dc.date.available2022-05-23T19:35:41Z
dc.date.issued2021-02-01
dc.description.abstractComplete removal of cancerous tissue and preservation of breast cosmesis with a single breast conserving surgery (BCS) is essential for surgeons. New and better options would allow them to more consistently achieve this goal and expand the number of women that receive this preferred therapy, while minimizing the need for re-excision and revision procedures or more aggressive surgical approaches (i.e., mastectomy). We have developed and evaluated a regenerative tissue filler that is applied as a liquid to defects during BCS prior to transitioning to a fibrillar collagen scaffold with soft tissue consistency. Using a porcine simulated BCS model, the collagen filler was shown to induce a regenerative healing response, characterized by rapid cellularization, vascularization, and progressive breast tissue neogenesis, including adipose tissue and mammary glands and ducts. Unlike conventional biomaterials, no foreign body response or inflammatory-mediated “active” biodegradation was observed. The collagen filler also did not compromise simulated surgical re-excision, radiography, or ultrasonography procedures, features that are important for clinical translation. When post-BCS radiation was applied, the collagen filler and its associated tissue response were largely similar to non-irradiated conditions; however, as expected, healing was modestly slower. This in situ scaffold-forming collagen is easy to apply, conforms to patient-specific defects, and regenerates complex soft tissues in the absence of inflammation. It has significant translational potential as the first regenerative tissue filler for BCS as well as other soft tissue restoration and reconstruction needs.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationPuls TJ, Fisher CS, Cox A, et al. Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs. Sci Rep. 2021;11(1):2711. Published 2021 Feb 1. doi:10.1038/s41598-021-81771-xen_US
dc.identifier.urihttps://hdl.handle.net/1805/29127
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionof10.1038/s41598-021-81771-xen_US
dc.relation.journalScientific Reportsen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0*
dc.sourcePMCen_US
dc.subjectSurgical oncologyen_US
dc.subjectPreclinical researchen_US
dc.subjectTranslational researchen_US
dc.subjectBiomaterialsen_US
dc.subjectRegenerative medicineen_US
dc.subjectTissue engineeringen_US
dc.titleRegenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needsen_US
dc.typeArticleen_US
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