Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders

dc.contributor.authorKhanna, Rajesh
dc.contributor.authorWilson, Sarah M.
dc.contributor.authorBrittain, Joel M.
dc.contributor.authorWeimer, Jill
dc.contributor.authorSultana, Rukhsana
dc.contributor.authorButterfield, Allan
dc.contributor.authorHensley, Kenneth
dc.contributor.departmentPharmacology and Toxicology, School of Medicine
dc.date.accessioned2025-05-28T09:19:37Z
dc.date.available2025-05-28T09:19:37Z
dc.date.issued2012
dc.description.abstractCRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by this protein. Together with its canonical roles in neurite growth and retraction and kinesin-dependent axonal transport, it is now known that CRMP2 interacts with numerous binding partners to affect microtubule dynamics; protein endocytosis and vesicular cycling, synaptic assembly, calcium channel regulation and neurotransmitter release. CRMP2 signaling is regulated by post-translational modifications, including glycosylation, oxidation, proteolysis and phosphorylation; the latter being a fulcrum of CRMP2 functions. Here, the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders are discussed and evidence is presented for therapeutic strategies targeting CRMP2 functions.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationKhanna R, Wilson SM, Brittain JM, et al. Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol. 2012;7(6):749-771. doi:10.2217/FNL.12.68
dc.identifier.urihttps://hdl.handle.net/1805/48425
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.relation.isversionof10.2217/FNL.12.68
dc.relation.journalFuture Neurology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAlzheimer’s disease
dc.subjectAmyotrophic lateral sclerosis
dc.subjectAxon elongation
dc.subjectExcitotoxicity
dc.subjectMultiple sclerosis
dc.subjectNeuropathic pain
dc.subjectOxidative damage
dc.titleOpening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders
dc.typeArticle
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