Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders
dc.contributor.author | Khanna, Rajesh | |
dc.contributor.author | Wilson, Sarah M. | |
dc.contributor.author | Brittain, Joel M. | |
dc.contributor.author | Weimer, Jill | |
dc.contributor.author | Sultana, Rukhsana | |
dc.contributor.author | Butterfield, Allan | |
dc.contributor.author | Hensley, Kenneth | |
dc.contributor.department | Pharmacology and Toxicology, School of Medicine | |
dc.date.accessioned | 2025-05-28T09:19:37Z | |
dc.date.available | 2025-05-28T09:19:37Z | |
dc.date.issued | 2012 | |
dc.description.abstract | CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by this protein. Together with its canonical roles in neurite growth and retraction and kinesin-dependent axonal transport, it is now known that CRMP2 interacts with numerous binding partners to affect microtubule dynamics; protein endocytosis and vesicular cycling, synaptic assembly, calcium channel regulation and neurotransmitter release. CRMP2 signaling is regulated by post-translational modifications, including glycosylation, oxidation, proteolysis and phosphorylation; the latter being a fulcrum of CRMP2 functions. Here, the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders are discussed and evidence is presented for therapeutic strategies targeting CRMP2 functions. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Khanna R, Wilson SM, Brittain JM, et al. Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol. 2012;7(6):749-771. doi:10.2217/FNL.12.68 | |
dc.identifier.uri | https://hdl.handle.net/1805/48425 | |
dc.language.iso | en_US | |
dc.publisher | Taylor & Francis | |
dc.relation.isversionof | 10.2217/FNL.12.68 | |
dc.relation.journal | Future Neurology | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Alzheimer’s disease | |
dc.subject | Amyotrophic lateral sclerosis | |
dc.subject | Axon elongation | |
dc.subject | Excitotoxicity | |
dc.subject | Multiple sclerosis | |
dc.subject | Neuropathic pain | |
dc.subject | Oxidative damage | |
dc.title | Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders | |
dc.type | Article |