Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

dc.contributor.authorSnell, K.
dc.contributor.authorNatsumedal, Y.
dc.contributor.authorEble, J. N.
dc.contributor.authorGlover, J. L.
dc.contributor.authorWeber, G.
dc.contributor.departmentSurgery, School of Medicine
dc.date.accessioned2025-03-28T08:25:07Z
dc.date.available2025-03-28T08:25:07Z
dc.date.issued1988
dc.description.abstractThe activities of 3-phosphoglycerate dehydrogenase, an enzyme of serine biosynthesis, and serine hydroxymethyltransferase, serine dehydratase and serine aminotransferase, which are competing enzymes of serine utilization, were assayed in human colon carcinomas from patients and in transplantable rat sarcomas. Serine dehydratase and serine aminotransferase activities were absent, whereas 3-phosphoglycerate dehydrogenase and serine hydroxymethyltransferase activities were markedly increased in both tumour types. Serine hydroxymethyltransferase catalyses the formation of glycine and methylene tetrahydrofolate which are important precursors for nucleotide biosynthesis. The observed enzymic imbalance in these tumours ensures that an increased capacity for the synthesis of serine is coupled to its utilisation for nucleotide biosynthesis as a part of the biochemical commitment to cellular replication in cancer cells. That this pattern is found in sarcomas and carcinomas, and in tumours of human and rodent origin, signifies its universal importance for the biochemistry of the cancer cell and singles it out as a potential target site for anti-cancer chemotherapy.
dc.eprint.versionFinal published version
dc.identifier.citationSnell K, Natsumeda Y, Eble JN, Glover JL, Weber G. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br J Cancer. 1988;57(1):87-90. doi:10.1038/bjc.1988.15
dc.identifier.urihttps://hdl.handle.net/1805/46627
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/bjc.1988.15
dc.relation.journalBritish Journal of Cancer
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectCarbohydrate dehydrogenases
dc.subjectColonic neoplasms
dc.subjectPhosphoglycerate dehydrogenase
dc.subjectRhabdomyosarcoma
dc.subjectTransaminases
dc.titleEnzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Snell1988Enzymic-CCBY.pdf
Size:
815.62 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.04 KB
Format:
Item-specific license agreed upon to submission
Description: