Host-targeting of virulence determinants and phosphoinositides in blood stage malaria parasites
| dc.contributor.author | Bhattacharjee, Souvik | |
| dc.contributor.author | Stahelin, Robert V. | |
| dc.contributor.author | Haldar, Kasturi | |
| dc.contributor.department | Biochemistry and Molecular Biology, School of Medicine | |
| dc.date.accessioned | 2025-06-12T10:04:48Z | |
| dc.date.available | 2025-06-12T10:04:48Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Blood stage malaria parasites target a 'secretome' of hundreds of proteins including virulence determinants containing a host (cell) targeting (HT) signal, to human erythrocytes. Recent studies reveal that the export mechanism is due to the HT signal binding to the lipid phosphatidylinositol-3-phosphate [PI(3)P] in the parasite endoplasmic reticulum (ER). An aspartic protease plasmepsin V which cleaves a specialized form of the HT signal was previously thought to be the export mechanism, but is now recognized as a dedicated peptidase that cleaves the signal anchor subsequent to PI(3)P binding. We discuss a model of PI(3)P-dependent targeting and PI(3)P biology of a major human pathogen. | |
| dc.eprint.version | Author's manuscript | |
| dc.identifier.citation | Bhattacharjee S, Stahelin RV, Haldar K. Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites. Trends Parasitol. 2012;28(12):555-562. doi:10.1016/j.pt.2012.09.004 | |
| dc.identifier.uri | https://hdl.handle.net/1805/48635 | |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | |
| dc.relation.isversionof | 10.1016/j.pt.2012.09.004 | |
| dc.relation.journal | Trends in Parasitology | |
| dc.rights | Publisher Policy | |
| dc.source | PMC | |
| dc.subject | Malaria | |
| dc.subject | Phosphoinositides | |
| dc.subject | Host-targeting | |
| dc.subject | Pathogenic secretion | |
| dc.subject | Export | |
| dc.subject | Blood cells | |
| dc.subject | Endoplasmic reticulum | |
| dc.title | Host-targeting of virulence determinants and phosphoinositides in blood stage malaria parasites | |
| dc.type | Article |