Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents
dc.contributor.author | Margossian, Renee | |
dc.contributor.author | Williams, Paige L. | |
dc.contributor.author | Yu, Wendy | |
dc.contributor.author | Jacobson, Denise L. | |
dc.contributor.author | Geffner, Mitchell E. | |
dc.contributor.author | DiMeglio, Linda A. | |
dc.contributor.author | Van Dyke, Russell B. | |
dc.contributor.author | Spector, Stephen A. | |
dc.contributor.author | Schuster, Gertrud U. | |
dc.contributor.author | Stephensen, Charles B. | |
dc.contributor.author | Miller, Tracie L. | |
dc.contributor.author | Lipshultz, Steven E. | |
dc.contributor.author | Study (PHACS) for the Pediatric HIV/AIDS Cohort | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2020-11-04T17:30:29Z | |
dc.date.available | 2020-11-04T17:30:29Z | |
dc.date.issued | 2020-06-01 | |
dc.description.abstract | Background: Disordered bone mineral metabolism and low vitamin D concentrations are associated with cardiovascular abnormalities; few studies have evaluated this relationship in HIV-infected youth. Setting: Adolescent Master Protocol (AMP) is a Pediatric HIV/AIDS Cohort Study (PHACS) network study conducted across 14 United States sites. Methods: Among perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youth enrolled in AMP, we evaluated associations of vitamin D (measured as 25-hydroxyvitamin D [25OHD]), parathyroid hormone (PTH), calcium, phosphate, and fibroblast growth factor-23 (FGF-23) concentrations with echocardiographic measures of left ventricular (LV) structure, function and concentrations of NT-proBNP, a biomarker of cardiac damage. Results: Among 485 participants (305 PHIV, 180 PHEU) with echocardiograms and bone mineralization measures, low 25OHD (< 20 ng/mL) was common among all participants (48% PHIV and 44% PHEU), but elevated PTH (> 65 pg/mL) was identified more often among PHIV than PHEU participants (9% vs 3%, p=0.02). After adjusting for HIV status and demographic covariates, both low 25OHD and elevated PTH were associated with lower mean LV mass z-scores, while elevated PTH was associated with higher mean fractional shortening z-scores. Participants with low 25OHD also had slightly higher mean LV end-systolic wall stress z-scores, but differences were more pronounced in PHEU than in PHIV participants. FGF-23 was inversely related to end-diastolic septal thickness both overall and among PHIV participants. Conclusion: In this cohort of PHIV and PHEU youth, we observed associations of 25OHD, PTH, and FGF-23 with both structural and functional cardiac parameters, supporting links between bone mineral metabolism and cardiac status. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Margossian, R., Williams, P. L., Yu, W., Jacobson, D. L., Geffner, M. E., DiMeglio, L. A., Van Dyke, R. B., Spector, S. A., Schuster, G. U., Stephensen, C. B., Miller, T. L., Lipshultz, S. E., & Study (PHACS), for the P. H. C. (2019). Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents. JAIDS Journal of Acquired Immune Deficiency Syndromes, 81(2), 238–246. https://doi.org/10.1097/QAI.0000000000002007 | en_US |
dc.identifier.issn | 1525-4135 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/24265 | |
dc.publisher | Wolters Kluwer | en_US |
dc.relation.isversionof | 10.1097/QAI.0000000000002007 | en_US |
dc.relation.journal | JAIDS Journal of Acquired Immune Deficiency Syndromes | en_US |
dc.source | PMC | en_US |
dc.subject | 25-hydroxy-vitamin D | en_US |
dc.subject | parathyroid hormone | en_US |
dc.subject | cardiac function | en_US |
dc.subject | HIV infection | en_US |
dc.subject | children | en_US |
dc.title | Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents | en_US |
dc.type | Article | en_US |
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