Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

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dc.contributor.authorPeterson, Amalia
dc.contributor.authorSathe, Aditi
dc.contributor.authorZaras, Dimitrios
dc.contributor.authorYang, Yisu
dc.contributor.authorDurant, Alaina
dc.contributor.authorDeters, Kacie D.
dc.contributor.authorShashikumar, Niranjana
dc.contributor.authorPechman, Kimberly R.
dc.contributor.authorKim, Michael E.
dc.contributor.authorGao, Chenyu
dc.contributor.authorKhairi, Nazirah Mohd
dc.contributor.authorLi, Zhiyuan
dc.contributor.authorYao, Tianyuan
dc.contributor.authorHuo, Yuankai
dc.contributor.authorDumitrescu, Logan
dc.contributor.authorGifford, Katherine A.
dc.contributor.authorWilson, Jo Ellen
dc.contributor.authorCambronero, Francis E.
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorBeason-Held, Lori L.
dc.contributor.authorAn, Yang
dc.contributor.authorArfanakis, Konstantinos
dc.contributor.authorErus, Guray
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorTosun, Duygu
dc.contributor.authorToga, Arthur W.
dc.contributor.authorThompson, Paul M.
dc.contributor.authorMormino, Elizabeth C.
dc.contributor.authorHabes, Mohamad
dc.contributor.authorWang, Di
dc.contributor.authorZhang, Panpan
dc.contributor.authorSchilling, Kurt
dc.contributor.authorAlzheimer's Disease Neuroimaging Initiative (ADNI)
dc.contributor.authorBIOCARD Study Team; Alzheimer's Disease Sequencing Project (ADSP)
dc.contributor.authorAlbert, Marilyn
dc.contributor.authorKukull, Walter
dc.contributor.authorBiber, Sarah A.
dc.contributor.authorLandman, Bennett A.
dc.contributor.authorJohnson, Sterling C.
dc.contributor.authorSchneider, Julie
dc.contributor.authorBarnes, Lisa L.
dc.contributor.authorBennett, David A.
dc.contributor.authorJefferson, Angela L.
dc.contributor.authorResnick, Susan M.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorHohman, Timothy J.
dc.contributor.authorArcher, Derek B.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2025-02-20T08:14:58Z
dc.date.available2025-02-20T08:14:58Z
dc.date.issued2025
dc.description.abstractIntroduction: The effects of sex and apolipoprotein E (APOE)-Alzheimer's disease (AD) risk factors-on white matter microstructure are not well characterized. Methods: Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)-corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex and APOE ε4 carrier status. Results: Sex differences in FAFWcorr in projection tracts and APOE ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. Discussion: There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted. Highlights: Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity. Females generally have lower free water-corrected fractional anisotropy compared to males. APOE ε4 carriers tended to have higher free water than non-carriers.
dc.eprint.versionFinal Published Version
dc.identifier.citationPeterson A, Sathe A, Zaras D, et al. Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease. Alzheimers Dement. 2025;21(1):e14343. doi:10.1002/alz.14343
dc.identifier.urihttps://hdl.handle.net/1805/45864
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/alz.14343
dc.relation.journalAlzheimer's & Dementia
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectAlzheimer's disease
dc.subjectAging
dc.subjectSex differences
dc.subjectWhite matter disease
dc.titleSex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease
dc.typeArticle
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