Direct Aerobic Carbonylation of C(sp2)-H and C(sp3)-H Bonds through Ni/Cu Synergistic Catalysis with DMF as the CO Source
dc.contributor.author | Wu, Xuesong | |
dc.contributor.author | Zhao, Yan | |
dc.contributor.author | Ge, Haibo | |
dc.contributor.department | Department of Chemistry & Chemical Biology, IU School of Science | en_US |
dc.date.accessioned | 2015-09-03T19:13:15Z | |
dc.date.available | 2015-09-03T19:13:15Z | |
dc.date.issued | 2015-03 | |
dc.description.abstract | The direct carbonylation of aromatic sp2 and unactivated sp3 C–H bonds of amides was achieved via nickel/copper catalysis under atmospheric O2 with the assistance of a bidentate directing group. The sp2 C–H functionalization showed high regioselectivity and good functional group compatibility. The sp3 C–H functionalization showed high site-selectivity by favoring the C–H bonds of α-methyl groups over those of the α-methylene, β- or γ-methyl groups. Moreover, this reaction showed a predominant preference for functionalizing the α-methyl over α-phenyl group. Mechanistic studies revealed that nickel/copper synergistic catalysis is involved in this process. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Wu, X., Zhao, Y., & Ge, H. (2015). Direct Aerobic Carbonylation of C (sp2)–H and C (sp3)–H Bonds through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source. Journal of the American Chemical Society, 137(15), 4924-4927. | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/6737 | |
dc.language.iso | en_US | en_US |
dc.publisher | ACS | en_US |
dc.relation.isversionof | 10.1021/jacs.5b01671 | en_US |
dc.relation.journal | Journal of the American Chemical Society | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | direct carbonylation | en_US |
dc.subject | nickel/copper catalysis | en_US |
dc.title | Direct Aerobic Carbonylation of C(sp2)-H and C(sp3)-H Bonds through Ni/Cu Synergistic Catalysis with DMF as the CO Source | en_US |
dc.type | Article | en_US |