Direct Aerobic Carbonylation of C(sp2)-H and C(sp3)-H Bonds through Ni/Cu Synergistic Catalysis with DMF as the CO Source

dc.contributor.authorWu, Xuesong
dc.contributor.authorZhao, Yan
dc.contributor.authorGe, Haibo
dc.contributor.departmentDepartment of Chemistry & Chemical Biology, IU School of Scienceen_US
dc.date.accessioned2015-09-03T19:13:15Z
dc.date.available2015-09-03T19:13:15Z
dc.date.issued2015-03
dc.description.abstractThe direct carbonylation of aromatic sp2 and unactivated sp3 C–H bonds of amides was achieved via nickel/copper catalysis under atmospheric O2 with the assistance of a bidentate directing group. The sp2 C–H functionalization showed high regioselectivity and good functional group compatibility. The sp3 C–H functionalization showed high site-selectivity by favoring the C–H bonds of α-methyl groups over those of the α-methylene, β- or γ-methyl groups. Moreover, this reaction showed a predominant preference for functionalizing the α-methyl over α-phenyl group. Mechanistic studies revealed that nickel/copper synergistic catalysis is involved in this process.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationWu, X., Zhao, Y., & Ge, H. (2015). Direct Aerobic Carbonylation of C (sp2)–H and C (sp3)–H Bonds through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source. Journal of the American Chemical Society, 137(15), 4924-4927.en_US
dc.identifier.urihttps://hdl.handle.net/1805/6737
dc.language.isoen_USen_US
dc.publisherACSen_US
dc.relation.isversionof10.1021/jacs.5b01671en_US
dc.relation.journalJournal of the American Chemical Societyen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectdirect carbonylationen_US
dc.subjectnickel/copper catalysisen_US
dc.titleDirect Aerobic Carbonylation of C(sp2)-H and C(sp3)-H Bonds through Ni/Cu Synergistic Catalysis with DMF as the CO Sourceen_US
dc.typeArticleen_US
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