Recent advances in Tumor Treating Fields (TTFields) therapy for glioblastoma

dc.contributor.authorKhagi, Simon
dc.contributor.authorKotecha, Rupesh
dc.contributor.authorGatson, Na Tosha N.
dc.contributor.authorJeyapalan, Suriya
dc.contributor.authorAbdullah, Huda Ismail
dc.contributor.authorAvgeropoulos, Nicholas G.
dc.contributor.authorBatzianouli, Eleni T.
dc.contributor.authorGiladi, Moshe
dc.contributor.authorLustgarten, Leonardo
dc.contributor.authorGoldlust, Samuel A.
dc.contributor.departmentNeurology, School of Medicine
dc.date.accessioned2025-04-21T13:57:43Z
dc.date.available2025-04-21T13:57:43Z
dc.date.issued2025
dc.description.abstractTumor Treating Fields (TTFields) therapy is a locoregional, anticancer treatment consisting of a noninvasive, portable device that delivers alternating electric fields to tumors through arrays placed on the skin. Based on efficacy and safety data from global pivotal (randomized phase III) clinical studies, TTFields therapy (Optune Gio) is US Food and Drug Administration-approved for newly diagnosed (nd) and recurrent glioblastoma (GBM) and Conformité Européenne-marked for grade 4 glioma. Here we review data on the multimodal TTFields mechanism of action that includes disruption of cancer cell mitosis, inhibition of DNA replication and damage response, interference with cell motility, and enhancement of systemic antitumor immunity (adaptive immunity). We describe new data showing that TTFields therapy has efficacy in a broad range of patients, with a tolerable safety profile extending to high-risk subpopulations. New analyses of clinical study data also confirmed that overall and progression-free survival positively correlated with increased usage of the device and dose of TTFields at the tumor site. Additionally, pilot/early phase clinical studies evaluating TTFields therapy in ndGBM concomitant with immunotherapy as well as radiotherapy have shown promise, and new pivotal studies will explore TTFields therapy in these settings. Finally, we review recent and ongoing studies in patients in pediatric care, other central nervous system tumors and brain metastases, as well as other advanced-stage solid tumors (ie, lung, ovarian, pancreatic, gastric, and hepatic cancers), that highlight the broad potential of TTFields therapy as an adjuvant treatment in oncology.
dc.eprint.versionFinal published version
dc.identifier.citationKhagi S, Kotecha R, Gatson NTN, et al. Recent advances in Tumor Treating Fields (TTFields) therapy for glioblastoma. Oncologist. 2025;30(2):oyae227. doi:10.1093/oncolo/oyae227
dc.identifier.urihttps://hdl.handle.net/1805/47234
dc.language.isoen_US
dc.publisherOxford University Press
dc.relation.isversionof10.1093/oncolo/oyae227
dc.relation.journalOncologist
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectTumor Treating Fields
dc.subjectAlternating electric field
dc.subjectAntitumor immunity
dc.subjectBrain tumor
dc.subjectGlioblastoma
dc.subjectMedical device
dc.titleRecent advances in Tumor Treating Fields (TTFields) therapy for glioblastoma
dc.typeArticle
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