Intestinal Perforation: A Rare Complication of Treatment With Bevacizumab

dc.contributor.authorAdhikari, Ramesh
dc.contributor.authorGhose, Medha
dc.contributor.authorTekin, Aysun
dc.contributor.authorSingh, Simranjit
dc.contributor.authorSingh, Romil
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-08-26T12:12:17Z
dc.date.available2022-08-26T12:12:17Z
dc.date.issued2021-03-24
dc.description.abstractBevacizumab, a monoclonal immunoglobulin-G1 antibody directed against vascular endothelial growth factor (VEGF), inhibits angiogenesis. Gastrointestinal perforation is a serious and often fatal adverse event related to bevacizumab use. Bevacizumab is indicated in the treatment of colorectal malignancies, certain subtypes of non-small cell lung carcinoma, metastatic renal cell carcinomas, and cervical cancers. It is also indicated in the treatment of recurrent glioblastoma (GBM) in adult patients as the sole treatment agent or in combination with other antineoplastic medications. We present a case of a patient on bevacizumab currently with glioblastoma multiforme and seizures, who was previously treated with radiation treatment and temozolomide. The patient presented to the emergency room with abdominal pain, seizures and was diagnosed to have an intestinal perforation.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationAdhikari R, Ghose M, Tekin A, Singh S, Singh R. Intestinal Perforation: A Rare Complication of Treatment With Bevacizumab. Cureus. 2021;13(3):e14093. Published 2021 Mar 24. doi:10.7759/cureus.14093en_US
dc.identifier.urihttps://hdl.handle.net/1805/29901
dc.language.isoen_USen_US
dc.publisherCureusen_US
dc.relation.isversionof10.7759/cureus.14093en_US
dc.relation.journalCureusen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0*
dc.sourcePMCen_US
dc.subjectBevacizumaben_US
dc.subjectPerforationen_US
dc.subjectCanceren_US
dc.titleIntestinal Perforation: A Rare Complication of Treatment With Bevacizumaben_US
dc.typeArticleen_US
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