Skin Sympathetic Nerve Activity and the Short-Term QT Interval Variability in Patients With Electrical Storm
dc.contributor.author | Chen, Songwen | |
dc.contributor.author | Meng, Guannan | |
dc.contributor.author | Doytchinova, Anisiia | |
dc.contributor.author | Wong, Johnson | |
dc.contributor.author | Straka, Susan | |
dc.contributor.author | Lacy, Julie | |
dc.contributor.author | Li, Xiaochun | |
dc.contributor.author | Chen, Peng-Sheng | |
dc.contributor.author | Everett, Thomas H., IV. | |
dc.contributor.department | Biostatistics, School of Public Health | en_US |
dc.date.accessioned | 2023-04-28T17:30:51Z | |
dc.date.available | 2023-04-28T17:30:51Z | |
dc.date.issued | 2021-12-22 | |
dc.description.abstract | Background: Skin sympathetic nerve activity (SKNA) and QT interval variability are known to be associated with ventricular arrhythmias. However, the relationship between the two remains unclear. Objective: The aim was to test the hypothesis that SKNA bursts are associated with greater short-term variability of the QT interval (STVQT) in patients with electrical storm (ES) or coronary heart disease without arrhythmias (CHD) than in healthy volunteers (HV). Methods: We simultaneously recorded the ECG and SKNA during sinus rhythm in patients with ES (N = 10) and CHD (N = 8) and during cold-water pressor test in HV (N = 12). The QT and QTc intervals were manually marked and calculated within the ECG. The STVQT was calculated and compared to episodes of SKNA burst and non-bursting activity. Results: The SKNA burst threshold for ES and HV was 1.06 ± 1.07 and 1.88 ± 1.09 μV, respectively (p = 0.011). During SKNA baseline and burst, the QT/QTc intervals and STVQT for ES and CHD were significantly higher than those of the HV. In all subjects, SKNA bursts were associated with an increased STVQT (from 6.43 ± 2.99 to 9.40 ± 5.12 ms, p = 0.002 for ES; from 9.48 ± 4.40 to 12.8 ± 5.26 ms, p = 0.016 for CHD; and from 3.81 ± 0.73 to 4.49 ± 1.24 ms, p = 0.016 for HV). The magnitude of increased STVQT in ES (3.33 ± 3.06 ms) and CHD (3.34 ± 2.34 ms) was both higher than that of the HV (0.68 ± 0.84 ms, p = 0.047 and p = 0.020). Conclusion: Compared to non-bursting activity, SKNA bursts were associated with a larger increase in the QTc interval and STVQT in patients with heart disease than in HV. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Chen S, Meng G, Doytchinova A, et al. Skin Sympathetic Nerve Activity and the Short-Term QT Interval Variability in Patients With Electrical Storm. Front Physiol. 2021;12:742844. Published 2021 Dec 22. doi:10.3389/fphys.2021.742844 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/32704 | |
dc.language.iso | en_US | en_US |
dc.publisher | Frontiers Media | en_US |
dc.relation.isversionof | 10.3389/fphys.2021.742844 | en_US |
dc.relation.journal | Frontiers in Physiology | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | QT interval | en_US |
dc.subject | Corrected QT interval | en_US |
dc.subject | Sympathetic nerve activity | en_US |
dc.subject | Electrical storm | en_US |
dc.subject | QT interval variability | en_US |
dc.subject | Sudden cardiac death | en_US |
dc.title | Skin Sympathetic Nerve Activity and the Short-Term QT Interval Variability in Patients With Electrical Storm | en_US |
dc.type | Article | en_US |