Recycled two-stage estimation in nonlinear mixed effects regression models
dc.contributor.author | Zhang, Yue | |
dc.contributor.author | Boukai, Ben | |
dc.contributor.department | Mathematical Sciences, School of Science | en_US |
dc.date.accessioned | 2023-01-20T20:56:35Z | |
dc.date.available | 2023-01-20T20:56:35Z | |
dc.date.issued | 2022-09 | |
dc.description.abstract | We consider a re-sampling scheme for estimation of the population parameters in the mixed-effects nonlinear regression models of the type used, for example, in clinical pharmacokinetics. We provide a two-stage estimation procedure which resamples (or recycles), via random weightings, the various parameter's estimates to construct consistent estimates of their respective sampling distributions. In particular, we establish under rather general distribution-free assumptions, the asymptotic normality and consistency of the standard two-stage estimates and of their resampled version and demonstrate the applicability of our proposed resampling methodology in a small simulation study. A detailed example based on real clinical pharmacokinetic data is also provided. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Zhang, Y., & Boukai, B. (2022). Recycled two-stage estimation in nonlinear mixed effects regression models. Statistical Methods & Applications, 31(3), 551–585. https://doi.org/10.1007/s10260-021-00581-7 | en_US |
dc.identifier.issn | 1618-2510, 1613-981X | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/30984 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | 10.1007/s10260-021-00581-7 | en_US |
dc.relation.journal | Statistical Methods & Applications | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | ArXiv | en_US |
dc.subject | Hierarchical nonlinear models | en_US |
dc.subject | Random weights | en_US |
dc.subject | resampling | en_US |
dc.title | Recycled two-stage estimation in nonlinear mixed effects regression models | en_US |
dc.type | Article | en_US |