Inherited Forms of Bladder Cancer: A review of Lynch Syndrome and Other Inherited Conditions
dc.contributor.author | Phelan, Aaron | |
dc.contributor.author | Lopez-Beltran, Antonio | |
dc.contributor.author | Montironi, Rodolfo | |
dc.contributor.author | Zhang, Shaobo | |
dc.contributor.author | Raspollini, Maria R. | |
dc.contributor.author | Kaimakliotis, Hristos Z. | |
dc.contributor.author | Koch, Michael O. | |
dc.contributor.author | Cheng, Liang | |
dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | en_US |
dc.date.accessioned | 2018-09-27T19:17:36Z | |
dc.date.available | 2018-09-27T19:17:36Z | |
dc.date.issued | 2018-02 | |
dc.description.abstract | Environmental factors that play a role in the urothelial carcinogenesis have been well characterized. Current research is continuously exploring potential heritable forms of bladder cancer. Lynch syndrome is a well-known inheritable disease that increases the risk for a variety of cancers, including urothelial carcinomas. Screening of patients with known Lynch syndrome is important to evaluate for development of new primary tumors. Further study may provide more information on what level of follow-up each patient needs. Recent data suggest that mismatch repair mutations confer a greater risk for urothelial cancer. Additional large patient series as well as advancement of molecular testing may provide triage for Lynch syndrome patients in regards to the frequency and type of screening best suited for individual patient. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Phelan, A., Lopez-Beltran, A., Montironi, R., Zhang, S., Raspollini, M. R., Cheng, M., … Cheng, L. (2018). Inherited forms of bladder cancer: a review of Lynch syndrome and other inherited conditions. Future Oncology, 14(3), 277–290. https://doi.org/10.2217/fon-2017-0346 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/17400 | |
dc.language.iso | en | en_US |
dc.publisher | Future Medicine | en_US |
dc.relation.isversionof | 10.2217/fon-2017-0346 | en_US |
dc.relation.journal | Future Oncology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | bladder cancer | en_US |
dc.subject | genetic susceptibility | en_US |
dc.subject | Lynch syndrome | en_US |
dc.title | Inherited Forms of Bladder Cancer: A review of Lynch Syndrome and Other Inherited Conditions | en_US |
dc.type | Article | en_US |