High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging

dc.contributor.authorZhao, Qi
dc.contributor.authorHolt, Abigail
dc.contributor.authorSpritzer, Charles E.
dc.contributor.authorDeFrate, Louis E.
dc.contributor.authorMcNulty, Amy L.
dc.contributor.authorWang, Nian
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2024-07-11T18:01:12Z
dc.date.available2024-07-11T18:01:12Z
dc.date.issued2024
dc.description.abstractBackground: Diffusion magnetic resonance imaging (MRI) allows for the quantification of water diffusion properties in soft tissues. The goal of this study was to characterize the 3D collagen fiber network in the porcine meniscus using high angular resolution diffusion imaging (HARDI) acquisition with both diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI). Methods: Porcine menisci (n=7) were scanned ex vivo using a three-dimensional (3D) HARDI spin-echo pulse sequence with an isotropic resolution of 500 µm at 7.0 Tesla. Both DTI and GQI reconstruction techniques were used to quantify the collagen fiber alignment and visualize the complex collagen network of the meniscus. The MRI findings were validated with conventional histology. Results: DTI and GQI exhibited distinct fiber orientation maps in the meniscus using the same HARDI acquisition. We found that crossing fibers were only resolved with GQI, demonstrating the advantage of GQI over DTI to visualize the complex collagen fiber orientation in the meniscus. Furthermore, the MRI findings were consistent with conventional histology. Conclusions: HARDI acquisition with GQI reconstruction more accurately resolves the complex 3D collagen architecture of the meniscus compared to DTI reconstruction. In the future, these technologies have the potential to nondestructively assess both normal and abnormal meniscal structure.
dc.eprint.versionFinal published version
dc.identifier.citationZhao Q, Holt A, Spritzer CE, DeFrate LE, McNulty AL, Wang N. High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging. Quant Imaging Med Surg. 2024;14(4):2738-2746. doi:10.21037/qims-23-1355
dc.identifier.urihttps://hdl.handle.net/1805/42134
dc.language.isoen_US
dc.publisherAME
dc.relation.isversionof10.21037/qims-23-1355
dc.relation.journalQuantitative Imaging in Medicine and Surgery
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePMC
dc.subjectDiffusion tensor imaging (DTI)
dc.subjectGeneralized q-sampling imaging (GQI)
dc.subjectTractography
dc.subjectMeniscus
dc.subjectHigh angular resolution diffusion imaging (HARDI)
dc.titleHigh angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging
dc.typeArticle
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