Liver Injury Associated with Kratom, A Popular Opioid-Like Product: Experience from the U.S. Drug Induced liver Injury Network

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dc.contributor.authorAhmad, Jawad
dc.contributor.authorOdin, Joseph A.
dc.contributor.authorHayashi, Paul H.
dc.contributor.authorFontana, Robert J.
dc.contributor.authorConjeevaram, Hari
dc.contributor.authorAvula, Bharathi
dc.contributor.authorKhan, Ikhlas A.
dc.contributor.authorBarnhart, Huiman
dc.contributor.authorVuppalanchi, Raj
dc.contributor.authorNavarro, Victor J.
dc.contributor.authorDrug-Induced Liver Injury Network
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-05-01T14:32:09Z
dc.date.available2023-05-01T14:32:09Z
dc.date.issued2021
dc.description.abstractBackground: Kratom is a botanical product used as an opium substitute with abuse potential. Methods: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort. Results: Eleven cases of liver injury attributed to kratom were identified with a recent increase. The majority were male with median age 40 years. All were symptomatic and developed jaundice with a median latency of 14 days. The liver injury pattern was variable, most required hospitalization and all eventually recovered. Biochemical analysis revealed active kratom ingredients. Conclusion: Kratom can cause severe liver injury with jaundice.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationAhmad J, Odin JA, Hayashi PH, et al. Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend. 2021;218:108426. doi:10.1016/j.drugalcdep.2020.108426en_US
dc.identifier.urihttps://hdl.handle.net/1805/32728
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.drugalcdep.2020.108426en_US
dc.relation.journalDrug and Alcohol Dependenceen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectKratomen_US
dc.subjectHepatotoxicityen_US
dc.subjectMitragynineen_US
dc.subject7-hydroxymitragynineen_US
dc.subjectOpioiden_US
dc.titleLiver Injury Associated with Kratom, A Popular Opioid-Like Product: Experience from the U.S. Drug Induced liver Injury Networken_US
dc.typeArticleen_US
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