LNCing RNA to Imm

dc.contributor.authorPeltier, Daniel C.
dc.contributor.authorRoberts, Alexis
dc.contributor.authorReddy, Pavan
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2025-04-11T10:40:03Z
dc.date.available2025-04-11T10:40:03Z
dc.date.issued2022
dc.description.abstractDespite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics and diagnostics for immune-mediated diseases. Long noncoding RNAs (lncRNAs) are versatile cell- and context-specific regulators of gene expression and cellular function. The number of lncRNA genes rivals that of protein-coding genes; however, comparatively little is known about their function. Even though the functions of most lncRNA genes are unknown, multiple lncRNAs have recently emerged as important immune regulators. Therefore, further unlocking the role of lncRNAs in the mammalian immune system coupled with their tissue-specific expression might lead to more precise therapeutics and diagnostics for immune disorders in general.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationPeltier DC, Roberts A, Reddy P. LNCing RNA to immunity. Trends Immunol. 2022;43(6):478-495. doi:10.1016/j.it.2022.04.002
dc.identifier.urihttps://hdl.handle.net/1805/46977
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.it.2022.04.002
dc.relation.journalTrends in Immunology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAlloimmunity
dc.subjectAntitumor immunity
dc.subjectAutoimmunity
dc.subjectImmunity
dc.subjectInflammatory immune disorders
dc.subjectLong noncoding RNA
dc.titleLNCing RNA to Imm
dc.typeArticle
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