Serum Hepcidin Levels Are Associated With Obesity but Not Liver Disease

dc.contributor.authorVuppalanchi, Raj
dc.contributor.authorTroutt, Jason S.
dc.contributor.authorKonrad, Robert J.
dc.contributor.authorGhabril, Marwan
dc.contributor.authorSaxena, Romil
dc.contributor.authorBell, Lauren N.
dc.contributor.authorKowdley, Kris V.
dc.contributor.authorChalasani, Naga
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-05-20T12:40:03Z
dc.date.available2025-05-20T12:40:03Z
dc.date.issued2014
dc.description.abstractObjective: Hepcidin is regulated by anemia and inflammation. It is primarily expressed in the liver but studies have reported its expression in adipose tissue. The relationship between BMI and serum hepcidin and the relationship between liver histology and serum hepcidin in the morbidly obese was investigated. Methods: Serum and liver tissue from patients undergoing bariatric surgery (bariatric cohort, n = 105) and serum from healthy blood donors (n = 60) were used to conduct this study. Serum hepcidin was measured using sandwich ELISA, highly specific for hepcidin-25. Serum ferritin, IL-6, IL-1β and liver function biochemistries were also measured. Results: After controlling for covariates, BMI ≥ 35 kg/m(2) was significantly associated with higher serum hepcidin level compared to individuals with lower BMI groups (17.7 ± 11.5 vs. 3.3 ± 4.7 ng/ml, P = 0.002). The presence of NAFLD was not associated with higher serum levels of hepcidin (multivariate P = 0.37). There was no association between serum hepcidin levels and liver histology (presence of steatohepatitis, advanced fibrosis, or NAFLD activity score) in the bariatric cohort. Conclusions: Obesity, but not the presence of NAFLD was associated with serum hepcidin levels. There was no association between serum hepcidin and liver histology in the morbidly obese undergoing bariatric surgery.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationVuppalanchi R, Troutt JS, Konrad RJ, et al. Serum hepcidin levels are associated with obesity but not liver disease. Obesity (Silver Spring). 2014;22(3):836-841. doi:10.1002/oby.20403
dc.identifier.urihttps://hdl.handle.net/1805/48276
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/oby.20403
dc.relation.journalObesity
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectSerum hepcidin
dc.subjectObesity
dc.subjectFerritin
dc.subjectNon-alcoholic fatty liver disease
dc.titleSerum Hepcidin Levels Are Associated With Obesity but Not Liver Disease
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Vuppalanchi2014Serum-AAM.pdf
Size:
479.08 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.04 KB
Format:
Item-specific license agreed upon to submission
Description: