Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis
dc.contributor.author | McHenry, Megan S. | |
dc.contributor.author | McAteer, Carole I. | |
dc.contributor.author | Oyungu, Eren | |
dc.contributor.author | McDonald, Brenna C. | |
dc.contributor.author | Bosma, Chris B. | |
dc.contributor.author | Mpofu, Philani B. | |
dc.contributor.author | Deathe, Andrew R. | |
dc.contributor.author | Vreeman, Rachel C. | |
dc.contributor.department | Biostatistics, School of Public Health | en_US |
dc.date.accessioned | 2019-07-31T16:50:13Z | |
dc.date.available | 2019-07-31T16:50:13Z | |
dc.date.issued | 2018-02 | |
dc.description.abstract | CONTEXT: HIV-infected (HIV+) children have worse neurodevelopmental outcomes compared with HIV-uninfected children. However, little is known regarding the differences in neurodevelopment between young HIV+ children, HIV-exposed but uninfected (HEU) children, and HIV-unexposed and uninfected (HUU) children. OBJECTIVE: To systematically review and meta-analyze data on neurodevelopmental performance between young HIV+, HEU, and HUU children. DATA SOURCES: We systematically searched the following electronic bibliographic databases: Ovid Medline, Embase, PsycINFO, Education Resources Information Center, and the Cochrane Database of Systematic Reviews. STUDY SELECTION: Studies were selected on the basis of defined inclusion criteria. Titles, abstracts, and full texts were assessed by 2 independent reviewers. DATA EXTRACTION: Data were extracted by 2 independent reviewers and cross-checked by 2 additional reviewers. RESULTS: Forty-five studies were identified for inclusion in the systematic review, and of these, 11 were included in the meta-analysis on the basis of availability of Bayley Scales of Infant and Toddler Development scores. Within the meta-analysis, when compared with their HUU peers, HIV+ and HEU children had lower cognitive and motor scores. HIV+ and HEU children with antiretroviral (ARV) exposure had lower cognitive and motor scores compared with those without ARV exposure. LIMITATIONS: We were unable to control adequately for intravenous drug use, geographic location, or quality of the assessment independently. CONCLUSIONS: Both HIV+ and HEU children had worse developmental outcomes compared with HUU children. HIV+ and HEU children with ARV exposure also had worse developmental outcomes compared with those without exposure; however, these results should be interpreted with caution. More research is needed to identify the impact of ARV exposure on young children. | en_US |
dc.identifier.citation | McHenry, M. S., McAteer, C. I., Oyungu, E., McDonald, B. C., Bosma, C. B., Mpofu, P. B., … Vreeman, R. C. (2018). Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis. Pediatrics, 141(2), e20172888. doi:10.1542/peds.2017-2888 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/20063 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Academy of Pediatrics | en_US |
dc.relation.isversionof | 10.1542/peds.2017-2888 | en_US |
dc.relation.journal | Pediatrics | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Developmental disabilities | en_US |
dc.subject | HIV infections | en_US |
dc.subject | Infectious disease transmission | en_US |
dc.subject | Neuropsychological tests | en_US |
dc.subject | Pregnancy complications | en_US |
dc.title | Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810606/ | en_US |