The Role of Urocortins in Intracerebral Hemorrhage

dc.contributor.authorChoy, KerWoon
dc.contributor.authorTsai, Andy Po-Yi
dc.contributor.authorLin, Peter Bor-Chian
dc.contributor.authorWu, Meng-Yu
dc.contributor.authorLee, Chihyi
dc.contributor.authorAlias, Aspalilah
dc.contributor.authorPang, Cheng-Yoong
dc.contributor.authorLiew, Hock-Kean
dc.contributor.departmentNeurology, School of Medicineen_US
dc.date.accessioned2022-04-19T19:16:48Z
dc.date.available2022-04-19T19:16:48Z
dc.date.issued2020-01
dc.description.abstractIntracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ICH, resulting in a poor prognosis for the patients. Urocortin (UCN) is a 40-amino-acid endogenous neuropeptide that belongs to the corticotropin-releasing hormone (CRH) family. The effect of UCN is activated by binding to two G-protein coupled receptors, CRH-R1 and CRH-R2, which are expressed in brain neurons and glial cells in various brain regions. Current research has shown that UCN exerts neuroprotective effects in ICH models via anti-inflammatory effects, which generally reduced brain edema and reduced blood-brain barrier disruption. These effects gradually help in the improvement of the neurological outcome, and thus, UCN may be a potential therapeutic target in the treatment of ICH. This review summarizes the data published to date on the role of UCN in ICH and the possible protective mechanisms underlined.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationChoy KW, Tsai AP, Lin PB, Wu MY, Lee C, Alias A, Pang CY, Liew HK. The Role of Urocortins in Intracerebral Hemorrhage. Biomolecules. 2020 Jan 7;10(1):96. doi: 10.3390/biom10010096. PMID: 31935997; PMCID: PMC7022917.en_US
dc.identifier.urihttps://hdl.handle.net/1805/28577
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/biom10010096en_US
dc.relation.journalBiomoleculesen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMCen_US
dc.subjectCorticotropin-releasing hormone receptoren_US
dc.subjectEndogenous neuropeptideen_US
dc.subjectIntracerebral hemorrhageen_US
dc.subjectNeuroprotectiveen_US
dc.subjectUrocortinen_US
dc.titleThe Role of Urocortins in Intracerebral Hemorrhageen_US
dc.typeArticleen_US
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