Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

dc.contributor.authorWu, S
dc.contributor.authorHan, J
dc.contributor.authorVleugels, R A
dc.contributor.authorPuett, R
dc.contributor.authorLaden, F
dc.contributor.authorHunter, D J
dc.contributor.authorQureshi, A A
dc.contributor.departmentDepartment of Epidemiology, Richard M. Fairbanks School of Public Healthen_US
dc.date.accessioned2016-02-26T15:33:44Z
dc.date.available2016-02-26T15:33:44Z
dc.date.issued2014-04-01
dc.description.abstractBackground: Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case–control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), have not been evaluated simultaneously in prospective studies. Methods: We conducted a cohort study among 108 578 women in the Nurses' Health Study (1976–2006) to evaluate the relative risks of skin cancers with cumulative UV flux based on residential history in adulthood. Results: Risk of SCC and BCC was significantly lower for women in lower quintiles vs the highest quintile of cumulative UV flux (both P for trend <0.0001). The association between cumulative UV flux and risk of melanoma did not reach statistical significance. However, risk of melanoma appeared to be lower among women in lower quintiles vs the highest quintile of cumulative UV flux in lag analyses with 2–10 years between exposure and outcome. The multivariable-adjusted hazard ratios per 200 × 10−4 Robertson–Berger units increase in cumulative UV flux were 0.979 (95% confidence interval (CI): 0.933, 1.028) for melanoma, 1.072 (95% CI: 1.041, 1.103) for SCC, and 1.043 (95% CI: 1.034, 1.052) for BCC. Conclusions: Associations with cumulative UV exposure in adulthood among women differed for melanoma, SCC, and BCC, suggesting a potential variable role of UV radiation in adulthood in the carcinogenesis of the three major skin cancers.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationWu, S., Han, J., Vleugels, R. A., Puett, R., Laden, F., Hunter, D. J., & Qureshi, A. A. (2014). Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women. British Journal of Cancer, 110(7), 1855–1861. http://doi.org/10.1038/bjc.2014.43en_US
dc.identifier.issn0007-0920en_US
dc.identifier.urihttps://hdl.handle.net/1805/8524
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionof10.1038/bjc.2014.43en_US
dc.relation.journalBritish Journal of Canceren_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.sourcePublisheren_US
dc.subjectEnvironmental Exposureen_US
dc.subjectanalysisen_US
dc.subjectSkin Neoplasmsen_US
dc.subjectepidemiologyen_US
dc.subjectetiologyen_US
dc.subjectUltraviolet Raysen_US
dc.subjectadverse effectsen_US
dc.subjectbasal cell carcinomaen_US
dc.subjectmelanomaen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectskin canceren_US
dc.titleCumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in womenen_US
dc.typeArticleen_US
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