Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings
dc.contributor.author | Konrad, Emily R. | |
dc.contributor.author | Soo, Jeremy | |
dc.contributor.author | Conroy, Andrea L. | |
dc.contributor.author | Namasopo, Sophie | |
dc.contributor.author | Opoka, Robert O. | |
dc.contributor.author | Hawkes, Michael T. | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2023-09-11T17:02:20Z | |
dc.date.available | 2023-09-11T17:02:20Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Diagnostic biomarkers for childhood pneumonia could guide management and improve antibiotic stewardship in low-resource settings where chest x-ray (CXR) is not always available. In this cross-sectional study, we measured chitinase 3-like protein 1 (CHI3L1), surfactant protein D (SP-D), lipocalin-2 (LCN2), and tissue inhibitor of metalloproteinases-1 (TIMP-1) in Ugandan children under the age of five hospitalized with acute lower respiratory tract infection. We determined the association between biomarker levels and primary end-point pneumonia, indicated by CXR consolidation. We included 89 children (median age 11 months, 39% female). Primary endpoint pneumonia was present in 22 (25%). Clinical signs were similar in children with and without CXR consolidation. Broad-spectrum antibiotics (ceftriaxone) were administered in 83 (93%). Levels of CHI3L1, SP-D, LCN2 and TIMP-1 were higher in patients with primary end-point pneumonia compared to patients with normal CXR or other infiltrates. All markers were moderately accurate predictors of primary end-point pneumonia, with area under receiver operator characteristic curves of 0.66-0.70 (<0.05 for all markers). The probability of CXR consolidation increased monotonically with the number of markers above cut-off. Among 28 patients (31%) in whom all four markers were below the cut-off, the likelihood ratio of CXR consolidation was 0.11 (95%CI 0.015 to 0.73). CHI3L1, SP-D, LCN2 and TIMP-1 were associated with CXR consolidation in children with clinical pneumonia in a low-resource setting. Combinations of quantitative biomarkers may be useful to safely withhold antibiotics in children with a low probability of bacterial infection. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Konrad, E. R., Soo, J., Conroy, A. L., Namasopo, S., Opoka, R. O., & Hawkes, M. T. (2022). Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings. Pathogens and Global Health, 0(0), 1–9. https://doi.org/10.1080/20477724.2022.2160885 | |
dc.identifier.other | 36562081 | |
dc.identifier.uri | https://hdl.handle.net/1805/35527 | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis | |
dc.relation.isversionof | 10.1080/20477724.2022.2160885 | |
dc.relation.journal | Pathogens and Global Health | |
dc.rights | Publisher Policy | |
dc.source | Author | |
dc.subject | Africa | |
dc.subject | Pediatric pneumonia | |
dc.subject | biomarkers | |
dc.title | Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings | |
dc.type | Article |