Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

dc.contributor.authorTirkes, Temel
dc.contributor.authorYadav, Dhiraj
dc.contributor.authorConwell, Darwin L.
dc.contributor.authorTerrito, Paul R.
dc.contributor.authorZhao, Xuandong
dc.contributor.authorVenkatesh, Sudhakar K.
dc.contributor.authorKolipaka, Arunark
dc.contributor.authorLi, Liang
dc.contributor.authorPisegna, Joseph R.
dc.contributor.authorPandol, Stephen J.
dc.contributor.authorPark, Walter G.
dc.contributor.authorTopazian, Mark
dc.contributor.authorSerrano, Jose
dc.contributor.authorFogel, Evan L.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2021-04-20T16:30:15Z
dc.date.available2021-04-20T16:30:15Z
dc.date.issued2019-05-14
dc.description.abstractCharacteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T1-weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T1 relaxometry, ECV, T1-weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationTirkes, T., Yadav, D., Conwell, D. L., Territo, P. R., Zhao, X., Venkatesh, S. K., Kolipaka, A., Li, L., Pisegna, J. R., Pandol, S. J., Park, W. G., Topazian, M., Serrano, J., Fogel, E. L., & the Consortium for the Study of Chronic Pancreatitis, D., and Pancreatic Cancer. (2019). Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): A comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer. Abdominal Radiology, 44(8), 2809–2821. https://doi.org/10.1007/s00261-019-02049-5en_US
dc.identifier.issn2366-0058en_US
dc.identifier.urihttps://hdl.handle.net/1805/25686
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00261-019-02049-5en_US
dc.relation.journalAbdominal Radiologyen_US
dc.sourcePMCen_US
dc.subjectChronic pancreatitisen_US
dc.subjectMRIen_US
dc.subjectMRCPen_US
dc.subjectT1 mappingen_US
dc.subjectExtracellular volumeen_US
dc.subjectDiffusion-weighted imagingen_US
dc.subjectMR elastographyen_US
dc.titleMagnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic canceren_US
dc.typeArticleen_US
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