Metabolic activation of CaMKII by coenzyme A
dc.contributor.author | McCoy, Francis | |
dc.contributor.author | Darbandi, Rashid | |
dc.contributor.author | Lee, Hoi Chang | |
dc.contributor.author | Bharatham, Kavitha | |
dc.contributor.author | Moldoveanu, Tudor | |
dc.contributor.author | Royappa, Grace | |
dc.contributor.author | Dodd, Keela | |
dc.contributor.author | Lin, Wenwei | |
dc.contributor.author | Chen, Si-Ing | |
dc.contributor.author | Tangallapally, Rajendra P. | |
dc.contributor.author | Kurokawa, Manabu | |
dc.contributor.author | Lee, Richard E. | |
dc.contributor.author | Shelat, Anang | |
dc.contributor.author | Chen, Taosheng | |
dc.contributor.author | Green, Douglas R. | |
dc.contributor.author | Harris, Robert A. | |
dc.contributor.author | Lin, Sue-Hwa | |
dc.contributor.author | Fissore, Rafael A. | |
dc.contributor.author | Colbran, Roger J. | |
dc.contributor.author | Nutt, Leta K. | |
dc.contributor.department | Biochemistry & Molecular Biology, School of Medicine | en_US |
dc.date.accessioned | 2015-09-14T19:46:10Z | |
dc.date.available | 2015-09-14T19:46:10Z | |
dc.date.issued | 2013-11-07 | |
dc.description.abstract | Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating CaMKII. We found that CoA directly binds to the CaMKII regulatory domain in the absence of Ca(2+) to activate CaMKII in a calmodulin-dependent manner. Furthermore, we show that CoA inhibits apoptosis not only in X. laevis oocytes but also in Murine oocytes. These findings uncover a direct mechanism of CaMKII regulation by metabolism and further highlight the importance of metabolism in preserving oocyte viability. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | McCoy, F., Darbandi, R., Lee, H. C., Bharatham, K., Moldoveanu, T., Royappa, G., … Nutt, L. K. (2013). Metabolic activation of CaMKII by Coenzyme A. Molecular Cell, 52(3), 325–339. http://doi.org/10.1016/j.molcel.2013.08.043 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/6898 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.molcel.2013.08.043 | en_US |
dc.relation.journal | Molecular Cell | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Calcium/calmodulin-dependent protein kinase II | en_US |
dc.subject | Oocyte cell death | en_US |
dc.subject | Metabolic activity | en_US |
dc.title | Metabolic activation of CaMKII by coenzyme A | en_US |
dc.type | Article | en_US |