Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia

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dc.contributor.authorLiu, Xulin
dc.contributor.authorde Boer, Sterre C. M.
dc.contributor.authorCortez, Kasey
dc.contributor.authorPoos, Jackie M.
dc.contributor.authorIllán-Gala, Ignacio
dc.contributor.authorHeuer, Hilary
dc.contributor.authorForsberg, Leah K.
dc.contributor.authorCasaletto, Kaitlin
dc.contributor.authorMemel, Molly
dc.contributor.authorAppleby, Brian S.
dc.contributor.authorBarmada, Sami
dc.contributor.authorBozoki, Andrea
dc.contributor.authorClark, David
dc.contributor.authorCobigo, Yann
dc.contributor.authorDarby, Ryan
dc.contributor.authorDickerson, Bradford C.
dc.contributor.authorDomoto-Reilly, Kimiko
dc.contributor.authorGalasko, Douglas R.
dc.contributor.authorGeschwind, Daniel H.
dc.contributor.authorGhoshal, Nupur
dc.contributor.authorGraff-Radford, Neill R.
dc.contributor.authorGrant, Ian M.
dc.contributor.authorHsiung, Ging-Yuek Robin
dc.contributor.authorHonig, Lawrence S.
dc.contributor.authorHuey, Edward D.
dc.contributor.authorIrwin, David
dc.contributor.authorKantarci, Kejal
dc.contributor.authorLéger, Gabriel C.
dc.contributor.authorLitvan, Irene
dc.contributor.authorMackenzie, Ian R.
dc.contributor.authorMasdeu, Joseph C.
dc.contributor.authorMendez, Mario F.
dc.contributor.authorOnyike, Chiadi U.
dc.contributor.authorPascual, Belen
dc.contributor.authorPressman, Peter
dc.contributor.authorBayram, Ece
dc.contributor.authorRamos, Eliana Marisa
dc.contributor.authorRoberson, Erik D.
dc.contributor.authorRogalski, Emily
dc.contributor.authorBouzigues, Arabella
dc.contributor.authorRussell, Lucy L.
dc.contributor.authorFoster, Phoebe H.
dc.contributor.authorFerry-Bolder, Eve
dc.contributor.authorMasellis, Mario
dc.contributor.authorvan Swieten, John
dc.contributor.authorJiskoot, Lize
dc.contributor.authorSeelaar, Harro
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorLaforce, Robert
dc.contributor.authorGraff, Caroline
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorde Mendonça, Alexandre
dc.contributor.authorTiraboschi, Pietro
dc.contributor.authorSantana, Isabel
dc.contributor.authorGerhard, Alexander
dc.contributor.authorLevin, Johannes
dc.contributor.authorSorbi, Sandro
dc.contributor.authorOtto, Markus
dc.contributor.authorPasquier, Florence
dc.contributor.authorDucharme, Simon
dc.contributor.authorButler, Chris R.
dc.contributor.authorLe Ber, Isabelle
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorRowe, James B.
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorMoreno, Fermin
dc.contributor.authorBorroni, Barbara
dc.contributor.authorBoeve, Brad F.
dc.contributor.authorBoxer, Adam L.
dc.contributor.authorRosen, Howie J.
dc.contributor.authorPijnenburg, Yolande A. L.
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorALLFTD Consortium
dc.contributor.authorGENFI Consortium
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-05-14T11:17:01Z
dc.date.available2025-05-14T11:17:01Z
dc.date.issued2025
dc.description.abstractIntroduction: Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females. Methods: We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex. Results: Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe. Discussion: Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation. Highlights: Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
dc.eprint.versionFinal published version
dc.identifier.citationLiu X, de Boer SCM, Cortez K, et al. Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimers Dement. 2025;21(4):e14608. doi:10.1002/alz.14608
dc.identifier.urihttps://hdl.handle.net/1805/48093
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/alz.14608
dc.relation.journalAlzheimer's & Dementia
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectBehavioral variant frontotemporal dementia
dc.subjectClinical diagnosis
dc.subjectDiversity
dc.subjectSex difference
dc.titleSex differences in clinical phenotypes of behavioral variant frontotemporal dementia
dc.typeArticle
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