The world according to IL-9

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2023
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American English
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American Association of Immunologists
Abstract

Among the cytokines regulating immune cells, IL-9 has gained considerable attention for its ability to act on multiple cell types as a regulator of beneficial and pathologic immune responses. Yet, it is still not clearly defined how IL-9 impacts immune responses. IL-9 demonstrates a remarkable degree of tissue-specific functionality and has cellular sources that vary by tissue site and the context of the inflammatory milieu. Here, we provide perspective to summarize the biological activities of IL-9 and highlight cell type-specific roles in the immune pathogenesis of diseases. This perspective will be important in defining the diseases where targeting IL-9 as a therapeutic strategy would be beneficial and where it has the potential to complicate clinical outcomes.

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Pajulas A, Zhang J, Kaplan MH. The World according to IL-9. J Immunol. 2023;211(1):7-14. doi:10.4049/jimmunol.2300094
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Journal of Immunology
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Article
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