Should Men and Women be Managed Differently in Glaucoma?

dc.contributor.authorAbrams Tobe, Leslie
dc.contributor.authorHarris, Alon
dc.contributor.authorTrinidad, Jake
dc.contributor.authorChandrasekhar, Kaarthik
dc.contributor.authorCantor, Adam
dc.contributor.authorAbrams, John
dc.contributor.authorAmireskandari, Annahita
dc.contributor.authorSiesky, Brent
dc.contributor.departmentOphthalmology, School of Medicine
dc.date.accessioned2025-04-01T11:32:29Z
dc.date.available2025-04-01T11:32:29Z
dc.date.issued2012
dc.description.abstractIntroduction: To assess differences in associations of ocular perfusion pressure (OPP) as well as retinal and retrobulbar blood flow between men and women with primary open angle glaucoma (OAG). Methods: A total of 116 patients with OAG (age 66.9 ± 10.9 years, 70 females) participating in the Indianapolis Glaucoma Progression Study were assessed for OPP, retinal microcirculation, and retrobulbar blood flow. Confocal scanning laser Doppler flowmetry measured peripapillary retinal capillary blood flow. Color Doppler imaging measured peak systolic (PSV) and diastolic blood flow velocities and vascular resistance in the ophthalmic (OA), central retinal (CRA), and nasal and temporal short posterior ciliary arteries (N/T PCA). Bivariate Spearman correlation and multivariate linear regression analyses were performed. Results: In female patients with OAG, inferior retinal capillary flow was associated with OPP (r = 0.246, P = 0.044). In men, superior and inferior sector retinal blood flow was associated with OPP (r = -0.402, P = 0.006 and r = -0.357, P = 0.016, respectively). There was no statistically significant association between OPP and retrobulbar blood vessel flow velocities in male patients with OAG but there was an association between OA and TPCA PSV and OPP in female patients with OAG (r = 0.290, P = 0.015 and r = 0.357, P = 0.002, respectively). In female patients with OAG, multivariate regression showed no statistically significant effect of any variable on the superior retinal capillary blood flow, with CRA PSV as a sole predictor to the inferior retinal sector (partial rho = 0.302, P = 0.015) and in male patients with OAG, superior sector retinal capillary blood flow was independently associated with intraocular pressure (partial rho = -0.371, P = 0.016) and OPP (partial rho = -0.456, P = 0.002) with a trend of association with OPP in the inferior retina (partial rho = -0.301, P = 0.053). Conclusions: There was a positive linear association between retinal microcirculation and OPP in females and a negative association in males. Male and female patients with OAG may differ in their vascular autoregulation in response to changes in OPP.
dc.eprint.versionFinal published version
dc.identifier.citationAbrams Tobe L, Harris A, Trinidad J, et al. Should Men and Women be Managed Differently in Glaucoma?. Ophthalmol Ther. 2012;1(1):1. doi:10.1007/s40123-012-0001-0
dc.identifier.urihttps://hdl.handle.net/1805/46725
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isversionof10.1007/s40123-012-0001-0
dc.relation.journalOphthalmology and Therapy
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourcePMC
dc.subjectGlaucoma
dc.subjectHormone
dc.subjectOcular blood flow
dc.subjectOcular perfusion pressure
dc.titleShould Men and Women be Managed Differently in Glaucoma?
dc.typeArticle
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