Subcutaneous Nerve Stimulation Reduces Sympathetic Nerve Activity in Ambulatory Dogs with Myocardial Infarction
dc.contributor.author | Yuan, Yuan | |
dc.contributor.author | Zhao, Ye | |
dc.contributor.author | Wong, Johnson | |
dc.contributor.author | Tsai, Wei-Chung | |
dc.contributor.author | Jiang, Zhaolei | |
dc.contributor.author | Kabir, Ryan A. | |
dc.contributor.author | Han, Seongwook | |
dc.contributor.author | Shen, Changyu | |
dc.contributor.author | Fishbein, Michael C. | |
dc.contributor.author | Chen, Lan S. | |
dc.contributor.author | Chen, Zhenhui | |
dc.contributor.author | Everett, Thomas H., IV. | |
dc.contributor.author | Chen, Peng-Sheng | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2023-01-20T17:38:13Z | |
dc.date.available | 2023-01-20T17:38:13Z | |
dc.date.issued | 2020-07 | |
dc.description.abstract | Background: Subcutaneous nerve stimulation (ScNS) remodels the stellate ganglion and reduces stellate ganglion nerve activity (SGNA) in dogs. Acute myocardial infarction (MI) increases SGNA through nerve sprouting. Objective: The purpose of this study was to test the hypothesis that ScNS remodels the stellate ganglion and reduces SGNA in ambulatory dogs with acute MI. Methods: In the experimental group, a radio transmitter was implanted during the first sterile surgery to record nerve activity and an electrocardiogram, followed by a second sterile surgery to create MI. Dogs then underwent ScNS for 2 months. The average SGNA (aSGNA) was compared with that in a historical control group (n = 9), with acute MI monitored for 2 months without ScNS. Results: In the experimental group, the baseline aSGNA and heart rate were 4.08±0.35 μV and 98±12 beats/min, respectively. They increased within 1 week after MI to 6.91±1.91 μV (P=.007) and 107±10 beats/min (P=.028), respectively. ScNS reduced aSGNA to 3.46±0.44 μV (P<.039) and 2.14±0.50 μV (P<.001) at 4 and 8 weeks, respectively, after MI. In comparison, aSGNA at 4 and 8 weeks in dogs with MI but no ScNS was 8.26±6.31 μV (P=.005) and 10.82±7.86 μV (P=0002), respectively. Immunostaining showed confluent areas of remodeling in bilateral stellate ganglia and a high percentage of tyrosine hydroxylase-negative ganglion cells. Terminal deoxynucleotidyl transferase dUTP nick end labeling was positive in 26.61%±11.54% of ganglion cells in the left stellate ganglion and 15.94%±3.62% of ganglion cells in the right stellate ganglion. Conclusion: ScNS remodels the stellate ganglion, reduces SGNA, and suppresses cardiac nerve sprouting after acute MI. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Yuan Y, Zhao Y, Wong J, et al. Subcutaneous nerve stimulation reduces sympathetic nerve activity in ambulatory dogs with myocardial infarction. Heart Rhythm. 2020;17(7):1167-1175. doi:10.1016/j.hrthm.2020.02.006 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/30981 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.hrthm.2020.02.006 | en_US |
dc.relation.journal | Heart Rhythm | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Arrhythmias | en_US |
dc.subject | Cardiac nerve sprouting | en_US |
dc.subject | Electrical stimulation | en_US |
dc.subject | Immunostaining | en_US |
dc.subject | Stellate ganglion nerve activity | en_US |
dc.subject | Sudden cardiac death | en_US |
dc.subject | Sympathetic nerve activity | en_US |
dc.title | Subcutaneous Nerve Stimulation Reduces Sympathetic Nerve Activity in Ambulatory Dogs with Myocardial Infarction | en_US |
dc.type | Article | en_US |