HUNK Signaling in Metastatic Breast Cancer

If you need an accessible version of this item, please submit a remediation request.
Date
2020-05-05
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Impact Journals
Abstract

Once metastatic disease has occurred, there is no cure for breast cancer. Consequently, identifying factors that promote and support breast cancer metastasis is critical for understanding how to pharmacologically target this process. Hormonally up-regulated neu-associated kinase (HUNK) is a serine/threonine protein kinase related to the sucrose non-fermenting-1 (Snf-1)/5’ adenosine monophosphate-activated protein kinase (AMPK) family of kinases. HUNK has been found to play a role in breast cancer metastasis. However, conflicting reports indicate HUNK is a metastasis promoting factor as well as an inhibiting factor. Our group recently provided evidence that supports the conclusion that HUNK is a metastasis promoting factor by showing that HUNK regulates breast cancer metastasis through phosphorylation of EGFR. Here, we summarize our findings and discuss their implications toward pharmacological targeting of HUNK in breast cancer.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Dilday, T., Ramos, N., & Yeh, E. (2020). HUNK Signaling in Metastatic Breast Cancer. Oncoscience, 7(5–6), 30–33. https://doi.org/10.18632/oncoscience.504
ISSN
2331-4737
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
Oncoscience
Source
PMC
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Full Text Available at
This item is under embargo {{howLong}}