Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models

dc.contributor.authorGanesan, Palanivel
dc.contributor.authorKim, Byungwook
dc.contributor.authorRamalaingam, Prakash
dc.contributor.authorKarthivashan, Govindarajan
dc.contributor.authorRevuri, Vishnu
dc.contributor.authorPark, Shinyoung
dc.contributor.authorKim, Joon Soo
dc.contributor.authorKo, Young Tag
dc.contributor.authorChoi, Dong-Kug
dc.contributor.departmentMedical and Molecular Genetics, School of Medicineen_US
dc.date.accessioned2019-08-09T14:45:20Z
dc.date.available2019-08-09T14:45:20Z
dc.date.issued2019-03-25
dc.description.abstractCurcumin, which is a potential antineuroinflammatory and neuroprotective compound, exhibits poor bioavailability in brain cells due to its difficulty in crossing the blood⁻brain barrier and its rapid metabolism during circulation, which decreases its efficacy in treating chronic neuroinflammatory diseases in the central nervous system. The bioavailability and potential of curcumin can be improved by using a nanodelivery system, which includes solid lipid nanoparticles. Curcumin-loaded solid lipid nanoparticles (SLCN) were efficiently developed to have a particle size of about 86 nm and do not exhibit any toxicity in the endothelial brain cells. Furthermore, the curcumin-loaded solid lipid nanoparticles (SLCN) were studied to assess their efficacy in BV-2 microglial cells against LPS-induced neuroinflammation. The SLCN showed a higher inhibition of nitric oxide (NO) production compared to conventional curcumin in a dose-dependent manner. Similarly, the mRNA and proinflammatory cytokine levels were also reduced in a dose-dependent manner when compared to those with free curcumin. Thus, SLCN could be a potential delivery system for curcumin to treat microglia-mediated neuroinflammation.en_US
dc.identifier.citationGanesan, P., Kim, B., Ramalaingam, P., Karthivashan, G., Revuri, V., Park, S., … Choi, D. K. (2019). Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models. Molecules (Basel, Switzerland), 24(6), 1170. doi:10.3390/molecules24061170en_US
dc.identifier.urihttps://hdl.handle.net/1805/20286
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/molecules24061170en_US
dc.relation.journalMoleculesen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcePMCen_US
dc.subjectSEMen_US
dc.subjectAntineuroinflammationen_US
dc.subjectCurcuminen_US
dc.subjectLipopolysaccharideen_US
dc.subjectSolid lipid nanoparticleen_US
dc.subjectToxicityen_US
dc.titleAntineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Modelsen_US
dc.typeArticleen_US
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