Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization

dc.contributor.authorDamania, Dhwanil
dc.contributor.authorRoy, Hemant K.
dc.contributor.authorSubramanian, Hariharan
dc.contributor.authorWeinberg, David S.
dc.contributor.authorRex, Douglas K.
dc.contributor.authorGoldberg, Michael J.
dc.contributor.authorMuldoon, Joseph
dc.contributor.authorCherkezyan, Lusik
dc.contributor.authorZhu, Yuanjia
dc.contributor.authorBianchi, Laura K.
dc.contributor.authorShah, Dhiren
dc.contributor.authorPradhan, Prabhakar
dc.contributor.authorBorkar, Monica
dc.contributor.authorLynch, Henry
dc.contributor.authorBackman, Vadim
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-07-07T12:44:16Z
dc.date.available2025-07-07T12:44:16Z
dc.date.issued2012
dc.description.abstractDeveloping a minimally invasive and cost-effective prescreening strategy for colon cancer is critical because of the impossibility of conducting colonoscopy on the entire at-risk population. The concept of field carcinogenesis, in which normal-appearing tissue away from a tumor has molecular and, consequently, nano-architectural abnormalities, offers one attractive approach to identify high-risk patients. In this study, we investigated whether the novel imaging technique partial wave spectroscopic (PWS) microscopy could risk-stratify patients harboring precancerous lesions of the colon, using an optically measured biomarker (L(d)) obtained from microscopically normal but nanoscopically altered cells. Rectal epithelial cells were examined from 146 patients, including 72 control patients, 14 patients with diminutive adenomas, 20 patients with nondiminutive/nonadvanced adenomas, 15 patients with advanced adenomas/high-grade dysplasia, 12 patients with genetic mutation leading to Lynch syndrome, and 13 patients with cancer. We found that the L(d) obtained from rectal colonocytes was well correlated with colon tumorigenicity in our patient cohort and in an independent validation set of 39 additional patients. Therefore, our findings suggest that PWS-measured L(d) is an accurate marker of field carcinogenesis. This approach provides a potential prescreening strategy for risk stratification before colonoscopy.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationDamania D, Roy HK, Subramanian H, et al. Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res. 2012;72(11):2720-2727. doi:10.1158/0008-5472.CAN-11-3807
dc.identifier.urihttps://hdl.handle.net/1805/49213
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dc.relation.isversionof10.1158/0008-5472.CAN-11-3807
dc.relation.journalCancer Research
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectNanocytology
dc.subjectNano-architecture
dc.subjectSub-diffractional sensitivity
dc.subjectField-carcinogenesis
dc.subjectColorectal cancer
dc.titleNanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization
dc.typeArticle
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