Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention
dc.contributor.author | Sims, Emily K. | |
dc.contributor.author | Geyer, Susan | |
dc.contributor.author | Bennett Johnson, Suzanne | |
dc.contributor.author | Libman, Ingrid | |
dc.contributor.author | Jacobsen, Laura M. | |
dc.contributor.author | Boulware, David | |
dc.contributor.author | Rafkin, Lisa E. | |
dc.contributor.author | Matheson, Della | |
dc.contributor.author | Atkinson, Mark A. | |
dc.contributor.author | Rodriguez, Henry | |
dc.contributor.author | Spall, Maria | |
dc.contributor.author | Elding Larsson, Helena | |
dc.contributor.author | Wherrett, Diane K. | |
dc.contributor.author | Greenbaum, Carla J. | |
dc.contributor.author | Krischer, Jeffrey | |
dc.contributor.author | DiMeglio, Linda A. | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2022-04-22T18:10:29Z | |
dc.date.available | 2022-04-22T18:10:29Z | |
dc.date.issued | 2019-12 | |
dc.description.abstract | Objective: To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study. Research design and methods: We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: 1) the return visit after screening to confirm an initial autoantibody-positive (Ab+) test result and 2) the initial oral glucose tolerance test (OGTT) for enrollment into the monitoring protocol. Results: Of 5,387 subjects who screened positive for a single autoantibody (Ab), 4,204 (78%) returned for confirmatory Ab testing. Younger age was associated with increased odds of returning for Ab confirmation (age <12 years vs. >18 years: odds ratio [OR] 2.12, P < 0.0001). Racial and ethnic minorities were less likely to return for confirmation, particularly nonwhite non-Hispanic (OR 0.50, P < 0.0001) and Hispanic (OR 0.69, P = 0.0001) relative to non-Hispanic white subjects. Of 8,234 subjects, 5,442 (66%) were identified as eligible to be enrolled in PTP OGTT monitoring. Here, younger age and identification as multiple Ab+ were associated with increased odds of returning for OGTT monitoring (age <12 years vs. >18 years: OR 1.43, P < 0.0001; multiple Ab+: OR 1.36, P < 0.0001). Parents were less likely to enroll into monitoring than other relatives (OR 0.78, P = 0.004). Site-specific factors, including site volume and U.S. site versus international site, were also associated with differences in rates of return for Ab+ confirmation and enrollment into monitoring. Conclusions: These data confirm clear differences between successfully enrolled populations and those lost to follow-up, which can serve to identify strategies to increase ongoing participation. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Sims EK, Geyer S, Johnson SB, et al. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention [published correction appears in Diabetes Care. 2020 Apr;43(4):934]. Diabetes Care. 2019;42(12):2228-2236. doi:10.2337/dc19-0593 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/28720 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Diabetes Association | en_US |
dc.relation.isversionof | 10.2337/dc19-0593 | en_US |
dc.relation.journal | Diabetes Care | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Type 1 diabetes | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | Glucose tolerance test | en_US |
dc.subject | Mass screening | en_US |
dc.title | Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention | en_US |
dc.type | Article | en_US |