Systematic review with meta-analysis: neoplasia detection rate and post-endoscopy Barrett’s neoplasia in Barrett’s oesophagus
dc.contributor.author | Hamade, Nour | |
dc.contributor.author | Kamboj, Amrit K. | |
dc.contributor.author | Krishnamoorthi, Rajesh | |
dc.contributor.author | Singh, Siddharth | |
dc.contributor.author | Hassett, Leslie C. | |
dc.contributor.author | Katzka, David A. | |
dc.contributor.author | Kahi, Charles J. | |
dc.contributor.author | Fatima, Hala | |
dc.contributor.author | Iyer, Prasad G. | |
dc.contributor.department | Medicine, School of Medicine | |
dc.date.accessioned | 2024-04-02T13:48:59Z | |
dc.date.available | 2024-04-02T13:48:59Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: Neoplasia detection rate, the proportion of Barrett's oesophagus patients with high-grade dysplasia or oesophageal adenocarcinoma detected at index surveillance endoscopy has been proposed as a quality metric. However, the correlation between neoplasia detection rate and a clinically relevant outcome like post-endoscopy Barrett's neoplasia remains unknown. Post-endoscopy Barrett's neoplasia refers to the rate of high-grade dysplasia or oesophageal adenocarcinoma on repeat endoscopy within one year of an index screening examination revealing non-dysplastic Barrett's oesophagus or low-grade dysplasia. Aim: To assess correlation between neoplasia detection rate and post-endoscopy Barrett's neoplasia. Methods: We performed a systematic search of multiple databases from date of inception to June 2021 to identify cohort studies reporting both neoplasia detection rate and post-endoscopy Barrett's neoplasia. Data from each study were pooled using a random effects model, and their correlation assessed using meta-regression. Heterogeneity was assessed and a priori planned subgroup analyses were conducted. Results: Ten studies with 27 894 patients with Barrett's oesophagus were included. The pooled neoplasia detection rate and post-endoscopy Barrett's neoplasia were 5.0% (95% CI: 3.4%-7.1%, I2 = 97%) and 19.6% (95% CI: 10.1%-34.7%, I2 = 96%), respectively. Meta-regression revealed a statistically significant inverse relationship between the two variables (coefficient -3.50, 95% CI: -4.63 to -2.37, P < 0.01). With every 1% increase of neoplasia detection rate, post-endoscopy Barrett's neoplasia decreased by 3.50%. Heterogeneity was high despite adjusting for study quality and performing several subgroup analyses. Conclusion: We observed a statistically significant inverse correlation between neoplasia detection rate and post-endoscopy Barrett's neoplasia. Additional studies are needed to further validate this correlation. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Hamade N, Kamboj AK, Krishnamoorthi R, et al. Systematic review with meta-analysis: neoplasia detection rate and post-endoscopy Barrett's neoplasia in Barrett's oesophagus. Aliment Pharmacol Ther. 2021;54(5):546-559. doi:10.1111/apt.16531 | |
dc.identifier.uri | https://hdl.handle.net/1805/39688 | |
dc.language.iso | en_US | |
dc.publisher | Wiley | |
dc.relation.isversionof | 10.1111/apt.16531 | |
dc.relation.journal | Alimentary Pharmacology and Therapeutics | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Adenocarcinoma | |
dc.subject | Barrett esophagus | |
dc.subject | Esophageal neoplasms | |
dc.subject | Hyperplasia | |
dc.title | Systematic review with meta-analysis: neoplasia detection rate and post-endoscopy Barrett’s neoplasia in Barrett’s oesophagus | |
dc.type | Article |