Metacarpophalangeal pattern profile analysis in fragile X syndrome

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dc.contributor.authorButler, M. G
dc.contributor.authorFletcher, M.
dc.contributor.authorGale, D. D.
dc.contributor.authorMeaney, F. J.
dc.contributor.authorMcLeod, D. R.
dc.contributor.authorFagan, J.
dc.contributor.authorCarpenter, N. J.
dc.contributor.authorOpitz, J. M.
dc.contributor.authorReynolds, J. F.
dc.contributor.departmentDepartment of Medical and Molecular Genetics, School of Medicineen_US
dc.date.accessioned2017-10-10T14:32:09Z
dc.date.available2017-10-10T14:32:09Z
dc.date.issued1988-12
dc.description.abstractWe analyzed the metacarpophalangeal pattern profile (MCPP) on 18 male individuals from 16 families with fragile X—fra (X), or Martin-Bell—syndrome and calculated a mean syndrome profile. Fourteen of 18 individuals with fra (X) syndrome had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with fra (X) syndrome compared with a sample of normal individuals produced a correct classification rate of 88% based on a function of 3 MCPP variables that may provide a useful tool in screening individuals for the fra (X) syndrome. Discriminant and correlation analyses of individuals with Sotos sequence and individuals with fra (X) syndrome did not identify MCPP similarities. Therefore, there was no MCPP evidence in our study of patients with Sotos sequence and fra (X) chromosome expression.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationButler, M. G., Fletcher, M., Gale, D. D., Meaney, F. J., McLeod, D. R., Fagan, J., & Carpenter, N. J. (1988). Metacarpophalangeal Pattern Profile Analysis in Fragile X Syndrome. American Journal of Medical Genetics, 31(4), 767–773. http://doi.org/10.1002/ajmg.1320310406en_US
dc.identifier.urihttps://hdl.handle.net/1805/14280
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ajmg.1320310406en_US
dc.relation.journalAmerican Journal of Medical Geneticsen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectSotos sequenceen_US
dc.subjectMetacarpophalangeal pattern profile (MCPP)en_US
dc.subjectPattern variability indexen_US
dc.subjectDiscriminant analysisen_US
dc.subjectCorrelation studiesen_US
dc.subjectMartin-Bell syndromeen_US
dc.titleMetacarpophalangeal pattern profile analysis in fragile X syndromeen_US
dc.typeArticleen_US
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