Metabolic Changes with Base-Loading in CKD

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dc.contributor.authorScialla, Julia J.
dc.contributor.authorBrown, Landon
dc.contributor.authorGurley, Susan
dc.contributor.authorCorcoran, David L.
dc.contributor.authorBain, James R.
dc.contributor.authorMuehlbauer, Michael J.
dc.contributor.authorO’Neal, Sara K.
dc.contributor.authorM. O’Connell, Thomas
dc.contributor.authorWolf, Myles
dc.contributor.authorMelamed, Michal L.
dc.contributor.authorHostetter, Thomas H.
dc.contributor.authorAbramowitz, Matthew K.
dc.contributor.departmentOtolaryngology -- Head and Neck Surgery, School of Medicineen_US
dc.date.accessioned2019-10-16T15:30:23Z
dc.date.available2019-10-16T15:30:23Z
dc.date.issued2018-08-07
dc.description.abstractIn small, randomized studies, treatment with sodium bicarbonate slowed kidney function decline in patients with CKD, possibly by lowering urine ammonium or inhibiting the renin-angiotensin-aldosterone or endothelin-1 pathways (1). Understanding the metabolic effects of alkali supplementation may reveal new candidate mechanisms. With this goal in mind, we profiled changes in systemic metabolites after treatment with sodium bicarbonate within a previously performed crossover trial of oral sodium bicarbonate (2).en_US
dc.identifier.citationScialla, J. J., Brown, L., Gurley, S., Corcoran, D. L., Bain, J. R., Muehlbauer, M. J., … Abramowitz, M. K. (2018). Metabolic Changes with Base-Loading in CKD. Clinical journal of the American Society of Nephrology : CJASN, 13(8), 1244–1246. doi:10.2215/CJN.01830218en_US
dc.identifier.urihttps://hdl.handle.net/1805/21173
dc.language.isoen_USen_US
dc.publisherAmerican Society of Nephrologyen_US
dc.relation.isversionof10.2215/CJN.01830218en_US
dc.relation.journalClinical Journal of the American Society of Nephrologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectRenal Insufficiencyen_US
dc.subjectChronicen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectChronic metabolic acidosisen_US
dc.subjectKidneyen_US
dc.subjectMetabolismen_US
dc.titleMetabolic Changes with Base-Loading in CKDen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086694/en_US
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