Baseline ultrasound and clinical correlates in children with cystic fibrosis.
dc.contributor.author | Leung, Daniel H. | |
dc.contributor.author | Ye, Wen | |
dc.contributor.author | Molleston, Jean P. | |
dc.contributor.author | Weymann, Alexander | |
dc.contributor.author | Ling, Simon | |
dc.contributor.author | Paranjape, Shruti M. | |
dc.contributor.author | Romero, Rene | |
dc.contributor.author | Schwarzenberg, Sara Jane | |
dc.contributor.author | Palermo, Joseph | |
dc.contributor.author | Alonso, Estella M. | |
dc.contributor.author | Murray, Karen F. | |
dc.contributor.author | Marshall, Bruce C. | |
dc.contributor.author | Sherker, Averell H. | |
dc.contributor.author | Siegel, Marilyn J. | |
dc.contributor.author | Krishnamurthy, Rajesh | |
dc.contributor.author | Harned, Roger | |
dc.contributor.author | Karmazyn, Boaz | |
dc.contributor.author | Magee, John C. | |
dc.contributor.author | Narkewicz, Michael R. | |
dc.contributor.department | Department of Pediatrics, IU School of Medicine | en_US |
dc.date.accessioned | 2016-12-08T23:30:40Z | |
dc.date.available | 2016-12-08T23:30:40Z | |
dc.date.issued | 2015-10 | |
dc.description.abstract | Objective: To investigate the relationship between abdominal ultrasound (US) findings and demographic, historical and clinical features in children with CF. Study design: Children age 3-12 years with CF without known cirrhosis, were enrolled in a prospective, multi-center study of US to predict hepatic fibrosis. Consensus US patterns were assigned by 3 radiologists as normal, heterogeneous, homogeneous, or cirrhosis. Data were derived from direct collection and U.S. or Toronto CF registries. Chi-square or ANOVA were used to compare variables among US groups and between normal and abnormal. Logistic regression was used to study risk factors for having abnormal US. Results: Findings in 719 subjects were normal (n=590, 82.1%), heterogeneous (64, 8.9%), homogeneous (41, 5.7%), and cirrhosis (24, 3.3%). Cirrhosis (p=0.0004), homogeneous (p<0.0001) and heterogeneous (p=0.03) were older than normal. More males were heterogeneous (p=0.001). More heterogeneous (15.0%, p=0.009) and cirrhosis (25.0%, p=0.005) had | en_US |
dc.eprint.version | Accepted Manuscript | en_US |
dc.identifier.citation | Leung, D. H., Ye, W., Molleston, J. P., Weymann, A., Ling, S., Paranjape, S. M., … Cystic Fibrosis Liver Disease Network (CFLD NET). (2015). Baseline Ultrasound and Clinical Correlates in Children with Cystic Fibrosis. The Journal of Pediatrics, 167(4), 862–868.e2. https://doi.org/10.1016/j.jpeds.2015.06.062 | |
dc.identifier.issn | 0022-3476 1097-6833 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11580 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jpeds.2015.06.062 | en_US |
dc.relation.journal | The Journal of pediatrics | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | BMI, Body mass index | en_US |
dc.subject | CF, Cystic fibrosis | en_US |
dc.subject | CFLD, CF liver disease | en_US |
dc.subject | CFLD NET, Cystic Fibrosis Liver Disease Network | en_US |
dc.subject | FEV1, Forced expiratory volume in 1 second | en_US |
dc.subject | NAFLD, Nonalcoholic fatty liver disease | en_US |
dc.subject | PUSH, Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis | en_US |
dc.title | Baseline ultrasound and clinical correlates in children with cystic fibrosis. | en_US |
dc.type | Article | en_US |
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