Apoptotic osteocytes and the control of targeted bone resorption

dc.contributor.authorPlotkin, Lilian I.
dc.contributor.departmentDepartment of Anatomy & Cell Biology, IU School of Medicineen_US
dc.date.accessioned2016-02-11T18:51:29Z
dc.date.available2016-02-11T18:51:29Z
dc.date.issued2014-03
dc.description.abstractStudies from the 1950s and 1960s already recognize the fact that osteocytes, although long living cells, die, as evidenced by accumulation of osteocytic lacunae devoid of cells. More recently, it was demonstrated that these cells die by apoptosis. The rate of osteocyte apoptosis is regulated by the age of the bone, as well as by systemic hormones, local growth factors, cytokines, pharmacological agents, and mechanical forces. Apoptotic osteocytes, in turn, recruit osteoclasts to initiate targeted bone resorption. This results in the removal of “dead” bone and may improve the mechanical properties of the skeleton. However, the molecular regulators of osteocyte survival and targeted bone remodeling are not completely known. In this review, the current knowledge on the molecular mechanism that lead to osteocyte death or survival, and the signals that mediate targeted bone resorption is discussed.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationPlotkin, L. I. (2014). Apoptotic osteocytes and the control of targeted bone resorption. Current Osteoporosis Reports, 12(1), 121–126. http://doi.org/10.1007/s11914-014-0194-3en_US
dc.identifier.urihttps://hdl.handle.net/1805/8299
dc.language.isoen_USen_US
dc.publisherSpringer USen_US
dc.relation.isversionof10.1007/s11914-014-0194-3en_US
dc.relation.journalCurrent Osteoporosis Reportsen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectOsteocytesen_US
dc.subjectApoptosisen_US
dc.subjectBone remodelingen_US
dc.titleApoptotic osteocytes and the control of targeted bone resorptionen_US
dc.typeArticleen_US
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