Calcitriol suppression of parathyroid hormone fails to improve skeletal properties in an animal model of chronic kidney disease

dc.contributor.authorNewman, Christopher L.
dc.contributor.authorTian, Nannan
dc.contributor.authorHammond, Max A.
dc.contributor.authorWallace, Joseph M.
dc.contributor.authorBrown, Drew M.
dc.contributor.authorChen, Neal X.
dc.contributor.authorMoe, Sharon M.
dc.contributor.authorAllen, Matthew R.
dc.contributor.departmentDepartment of Anatomy & Cell Biology, IU School of Medicineen_US
dc.date.accessioned2017-07-05T17:27:21Z
dc.date.available2017-07-05T17:27:21Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Chronic kidney disease (CKD) leads to complex metabolic changes and an increased risk of fracture. Currently, calcitriol is the standard of care as it effectively suppresses parathyroid hormone (PTH) levels in CKD patients. While calcitriol and its analogs improve BMD and reduce fractures in the general population, the extension of these benefits to patients with advanced kidney disease is unclear. Here, the impact of calcitriol on the skeleton was examined in the setting of reduction in PTH. METHODS: Male Cy/+ rats, a PKD-like CKD model, were treated with either vehicle or calcitriol for 5 weeks. Their normal littermates served as controls. Animals were assessed for changes in mineral metabolism and skeletal parameters (microCT, histology, whole bone mechanics and bone quality). RESULTS: PTH levels were significantly higher (12-fold) in animals with CKD compared to normal controls. CKD animals also exhibited negative changes in bone structural and mechanical properties. Calcitriol treatment resulted in a 60% suppression of PTH levels in animals with CKD. Despite these changes, it had no impact on bone volume (cortical or cancellous), bone turnover, osteoclast number or whole bone mechanical properties. CONCLUSIONS: These data indicate that while calcitriol effectively lowered PTH in rats with CKD, it did little to prevent the negative effects of secondary hyperparathyroidism on the skeleton.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationNewman, C. L., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, N. X., … Allen, M. R. (2016). Calcitriol suppression of parathyroid hormone fails to improve skeletal properties in an animal model of chronic kidney disease. American Journal of Nephrology, 43(1), 20–31. http://doi.org/10.1159/000444423en_US
dc.identifier.urihttps://hdl.handle.net/1805/13315
dc.language.isoen_USen_US
dc.publisherKargeren_US
dc.relation.isversionof10.1159/000444423en_US
dc.relation.journalAmerican Journal of Nephrologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAnimal modelsen_US
dc.subjectBone diseaseen_US
dc.subjectCKDen_US
dc.subjectTreatmenten_US
dc.subjectCalcitriolen_US
dc.titleCalcitriol suppression of parathyroid hormone fails to improve skeletal properties in an animal model of chronic kidney diseaseen_US
dc.typeArticleen_US
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