Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
dc.contributor.author | Halasa, Natasha B. | |
dc.contributor.author | Spieker, Andrew J. | |
dc.contributor.author | Young, Cameron C. | |
dc.contributor.author | Olson, Samantha M. | |
dc.contributor.author | Newhams, Margaret M. | |
dc.contributor.author | Amarin, Justin Z. | |
dc.contributor.author | Moffitt, Kristin L. | |
dc.contributor.author | Nakamura, Mari M. | |
dc.contributor.author | Levy, Emily R. | |
dc.contributor.author | Soma, Vijaya L. | |
dc.contributor.author | Talj, Rana | |
dc.contributor.author | Weiss, Scott L. | |
dc.contributor.author | Fitzgerald, Julie C. | |
dc.contributor.author | Mack, Elizabeth H. | |
dc.contributor.author | Maddux, Aline B. | |
dc.contributor.author | Schuster, Jennifer E. | |
dc.contributor.author | Coates, Bria M. | |
dc.contributor.author | Hall, Mark W. | |
dc.contributor.author | Schwartz, Stephanie P. | |
dc.contributor.author | Schwarz, Adam J. | |
dc.contributor.author | Kong, Michele | |
dc.contributor.author | Spinella, Philip C. | |
dc.contributor.author | Loftis, Laura L. | |
dc.contributor.author | McLaughlin, Gwenn E. | |
dc.contributor.author | Hobbs, Charlotte V. | |
dc.contributor.author | Rowan, Courtney M. | |
dc.contributor.author | Bembea, Melania M. | |
dc.contributor.author | Nofziger, Ryan A. | |
dc.contributor.author | Babbitt, Christopher J. | |
dc.contributor.author | Bowens, Cindy | |
dc.contributor.author | Flori, Heidi R. | |
dc.contributor.author | Gertz, Shira J. | |
dc.contributor.author | Zinter, Matt S. | |
dc.contributor.author | Giuliano, John S. | |
dc.contributor.author | Hume, Janet R. | |
dc.contributor.author | Cvijanovich, Natalie Z. | |
dc.contributor.author | Singh, Aalok R. | |
dc.contributor.author | Crandall, Hillary A. | |
dc.contributor.author | Thomas, Neal J. | |
dc.contributor.author | Cullimore, Melissa L. | |
dc.contributor.author | Patel, Manish M. | |
dc.contributor.author | Randolph, Adrienne G. | |
dc.contributor.author | Pediatric Intensive Care Influenza | |
dc.contributor.author | Overcoming COVID-19 Investigators | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2023-08-09T13:57:47Z | |
dc.date.available | 2023-08-09T13:57:47Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Background: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. Methods: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. Results: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32). Conclusions: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Halasa NB, Spieker AJ, Young CC, et al. Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clin Infect Dis. 2023;76(3):e280-e290. doi:10.1093/cid/ciac477 | |
dc.identifier.uri | https://hdl.handle.net/1805/34805 | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dc.relation.isversionof | 10.1093/cid/ciac477 | |
dc.relation.journal | Clinical Infectious Diseases | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | COVID-19 | |
dc.subject | SARS-CoV-2 | |
dc.subject | Children | |
dc.subject | Influenza | |
dc.subject | Intensive care units | |
dc.title | Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384330/ |