Enhancing immune checkpoint blockade therapy of genitourinary malignancies by co-targeting PMN-MDSCs

dc.contributor.authorLu, Xuemin
dc.contributor.authorLu, Xin
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2024-01-04T11:24:33Z
dc.date.available2024-01-04T11:24:33Z
dc.date.issued2022
dc.description.abstractImmune checkpoint blockade (ICB) as a powerful immunotherapy has transformed cancer treatment. The application of ICB to genitourinary malignancies has generated substantial clinical benefits for patients with advanced kidney cancer or bladder cancer, yet very limited response to ICB therapy was observed from metastatic castration-resistant prostate cancer. The efficacy of ICB in rare genitourinary tumors (e.g. penile cancer) awaits results from ongoing clinical trials. A potential barrier for ICB is tumor-infiltrating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) with their functions and mechanisms recently revealed. Preclinical studies suggest that successful therapeutic inhibition of PMN-MDSCs synergizes effectively with ICB to eradicate ICB-refractory genitourinary malignancies.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationLu X, Lu X. Enhancing immune checkpoint blockade therapy of genitourinary malignancies by co-targeting PMN-MDSCs. Biochim Biophys Acta Rev Cancer. 2022;1877(3):188702. doi:10.1016/j.bbcan.2022.188702
dc.identifier.urihttps://hdl.handle.net/1805/37597
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.bbcan.2022.188702
dc.relation.journalBiochimica et Biophysica Acta (BBA) - Reviews on Cancer
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectProstate cancer
dc.subjectRenal cell carcinoma
dc.subjectBladder cancer
dc.subjectPenile cancer
dc.subjectPenile squamous cell carcinoma
dc.subjectPolymorphonuclear myeloid-derived suppressor cell
dc.subjectImmunotherapy
dc.subjectCXCR2
dc.subjectReactive nitrogen species
dc.titleEnhancing immune checkpoint blockade therapy of genitourinary malignancies by co-targeting PMN-MDSCs
dc.typeArticle
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