Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity
dc.contributor.author | Peña, Armando | |
dc.contributor.author | Kim, Joon Young | |
dc.contributor.author | Reyes, Jessica A. | |
dc.contributor.author | Vander Wyst, Kiley B. | |
dc.contributor.author | Ayers, Stephanie L. | |
dc.contributor.author | Olson, Micah L. | |
dc.contributor.author | Williams, Allison N. | |
dc.contributor.author | Shaibi, Gabriel Q. | |
dc.contributor.department | Graduate Medical Education, School of Medicine | |
dc.date.accessioned | 2024-04-23T14:39:15Z | |
dc.date.available | 2024-04-23T14:39:15Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Glucose concentrations during an oral glucose tolerance test (OGTT) have been used as biomarkers to differentiate type 2 diabetes risk phenotypes. No studies have examined changes in OGTT-glucose phenotypes following lifestyle intervention among high-risk youth. Objective: To examine changes in OGTT-glucose phenotypes following lifestyle intervention and to explore differences in insulin sensitivity and β-cell function among post-intervention phenotypes. Methods: Latino adolescents with obesity (n = 48, age 15.4 ± 1.0, BMI% 98.2 ± 1.4, female 56.3%) completed a 12-week lifestyle intervention that included weekly nutrition education and physical activity. At baseline and 12 weeks, youth completed a 2-h OGTT with glucose and insulin concentrations assessed at 0', 30', 60', 90' and 120'. Glucose concentrations during the OGTT were used to identify biomarkers, 1-h glucose, glucose response curve and time to glucose peak. Using these respective biomarkers, high-risk (1-h glucose ≥ 155 mg/dl, Monophasic, Late Peak) and lower-risk phenotypes (1-h glucose < 155 mg/dl, Biphasic, Early Peak) were categorized. Insulin sensitivity was estimated by whole-body insulin sensitivity index (WBISI) and β-cell function by oral disposition index (oDI). Results: Following intervention, the prevalence of Monophasic phenotypes decreased from 81% to 67% (p = 0.048) and 1-h glucose ≥ 155 mg/dl from 38% to 10% (p = 0.054). Although Late Peak phenotypes did not significantly change (from 58% to 29%, p = 0.200), Early Peak phenotypes at post-intervention demonstrated significantly higher WBISI compared to Late Peak (2.3 ± 0.1 vs 1.7 ± 0.2, p = 0.023). Conclusions: OGTT-glucose phenotypes improve following lifestyle intervention among high-risk youth. These findings further support their potential utility as clinical biomarkers to identify diabetes risk and risk reduction in youth. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Peña A, Kim JY, Reyes JA, et al. Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity. Pediatr Obes. 2022;17(4):e12867. doi:10.1111/ijpo.12867 | |
dc.identifier.uri | https://hdl.handle.net/1805/40150 | |
dc.language.iso | en_US | |
dc.publisher | Wiley | |
dc.relation.isversionof | 10.1111/ijpo.12867 | |
dc.relation.journal | Pediatric Obesity | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Diabetes prevention | |
dc.subject | Exercise | |
dc.subject | Health behaviour | |
dc.subject | Nutrition | |
dc.subject | Physical activity | |
dc.title | Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity | |
dc.type | Article |