Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii

Simple item page
dc.contributor.authorStilger, Krista L.
dc.contributor.authorSullivan, William J., Jr.
dc.contributor.departmentPharmacology and Toxicology, School of Medicine
dc.date.accessioned2024-08-28T15:08:34Z
dc.date.available2024-08-28T15:08:34Z
dc.date.issued2013
dc.description.abstractBackground: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.
dc.eprint.versionFinal published version
dc.identifier.citationStilger KL, Sullivan WJ Jr. Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii. J Biol Chem. 2013;288(35):25318-25329. doi:10.1074/jbc.M113.491373
dc.identifier.urihttps://hdl.handle.net/1805/43009
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1074/jbc.M113.491373
dc.relation.journalJournal of Biological Chemistry
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectIron-sulfur protein
dc.subjectMembrane enzymes
dc.subjectMitochondria
dc.subjectParasite
dc.subjectPost-translational modification
dc.subjectProtein targeting
dc.subjectProtozoan
dc.subjectApicomplexa
dc.subjectElongator
dc.subjectAcetylation
dc.titleElongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Stilger2013Elongator-CCBY.pdf
Size:
2.79 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.04 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Pharmacology and Toxicology Works
William J. Sullivan, Jr.