Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis
| dc.contributor.author | Lammert, Craig | |
| dc.contributor.author | Shin, Andrea S. | |
| dc.contributor.author | Xu, Huiping | |
| dc.contributor.author | Hemmerich, Christopher | |
| dc.contributor.author | O’Connell, Thomas M. | |
| dc.contributor.author | Chalasani, Naga | |
| dc.contributor.department | Medicine, School of Medicine | en_US |
| dc.date.accessioned | 2023-06-07T09:19:09Z | |
| dc.date.available | 2023-06-07T09:19:09Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | The gut microbiota and metabolome could play a role in primary biliary cholangitis (PBC) progression. We aimed to assess fecal microbiota and fecal short-chain fatty acids (SCFAs) in PBC according to fibrosis. In a cross-sectional study of 23 PBC patients, fecal microbiota and SCFAs were determined using 16S rRNA sequencing and nuclear magnetic resonance spectroscopy, respectively. Fecal acetate and SCFAs were higher in advanced fibrosis. Advanced fibrosis microbiota exhibited decreased alpha diversity, increased Weisella and a distinct community composition. SCFAs correlated with individual taxa in non-advanced fibrosis. Fecal microbiota and SCFAs correspond to fibrosis in PBC. | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.identifier.citation | Lammert C, Shin A, Xu H, Hemmerich C, O'Connell TM, Chalasani N. Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis. FEMS Microbiol Lett. 2021;368(6):fnab038. doi:10.1093/femsle/fnab038 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/33522 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Oxford University Press | en_US |
| dc.relation.isversionof | 10.1093/femsle/fnab038 | en_US |
| dc.relation.journal | FEMS Microbiology Letters | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Acetate | en_US |
| dc.subject | Butyrate | en_US |
| dc.subject | Metabolome | en_US |
| dc.subject | Microbiome | en_US |
| dc.subject | Primary biliary cirrhosis | en_US |
| dc.subject | Propionate | en_US |
| dc.title | Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis | en_US |
| dc.type | Article | en_US |
| ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062329/ | en_US |