Current Progress in CAR-T Cell Therapy for Solid Tumors
dc.contributor.author | Ma, Shuo | |
dc.contributor.author | Li, Xinchun | |
dc.contributor.author | Wang, Xinyue | |
dc.contributor.author | Cheng, Liang | |
dc.contributor.author | Li, Zhong | |
dc.contributor.author | Zhang, Changzheng | |
dc.contributor.author | Ye, Zhenlong | |
dc.contributor.author | Qian, Qijun | |
dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | en_US |
dc.date.accessioned | 2020-01-09T17:57:18Z | |
dc.date.available | 2020-01-09T17:57:18Z | |
dc.date.issued | 2019-09-07 | |
dc.description.abstract | Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. Recently two CAR-T cell based therapeutics, Kymriah (Tisagenlecleucel) and Yescarta (Axicabtagene ciloleucel) approved by US FDA (US Food and Drug Administration) are now used for treatment of B cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL) respectively in the US. Despite the progresses made in treating hematological malignancies, challenges still remain for use of CAR-T cell therapy to treat solid tumors. In this landscape, most studies have primarily focused on improving CAR-T cells and overcoming the unfavorable effects of tumor microenvironment on solid tumors. To further understand the current status and trend for developing CAR-T cell based therapies for various solid tumors, this review emphasizes on CAR-T techniques, current obstacles, and strategies for application, as well as necessary companion diagnostics for treatment of solid tumors with CAR-T cells. | en_US |
dc.identifier.citation | Ma, S., Li, X., Wang, X., Cheng, L., Li, Z., Zhang, C., … Qian, Q. (2019). Current Progress in CAR-T Cell Therapy for Solid Tumors. International journal of biological sciences, 15(12), 2548–2560. doi:10.7150/ijbs.34213 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21806 | |
dc.language.iso | en_US | en_US |
dc.publisher | Ivyspring | en_US |
dc.relation.isversionof | 10.7150/ijbs.34213 | en_US |
dc.relation.journal | International Journal of Biological Sciences | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | CAR-T cells | en_US |
dc.subject | Chimeric antigen receptor | en_US |
dc.subject | Solid tumors | en_US |
dc.subject | Companion diagnostics | en_US |
dc.subject | CTC | en_US |
dc.title | Current Progress in CAR-T Cell Therapy for Solid Tumors | en_US |
dc.type | Article | en_US |