MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection
dc.contributor.author | Nguyen, Hai V. | |
dc.contributor.author | Gore, Jesse | |
dc.contributor.author | Zhong, Xin | |
dc.contributor.author | Savant, Sudha S. | |
dc.contributor.author | Deitz-McElyea, Samantha | |
dc.contributor.author | Schmidt, C. Max | |
dc.contributor.author | House, Michael G. | |
dc.contributor.author | Korc, Murray | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2018-03-14T16:23:10Z | |
dc.date.available | 2018-03-14T16:23:10Z | |
dc.date.issued | 2016-10 | |
dc.description.abstract | Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR. Expression was correlated with disease recurrence, recurrence-free survival (RFS), and overall survival (OS). Station 8 lymph nodes from 37 patients (30 periampullary carcinomas (PCs), 2 chronic pancreatitis, 5 other cancers) exhibited increased miRNA-10b levels in 14/30 PCs, and in 10 of these 14 patients, cancer recurred during the study period (2012–2015). High miRNA-10b was also associated with shorter RFS (42.5 vs. 92.4 weeks, p < 0.05) but not OS, whereas miRNA-30c, miRNA-21, and miRNA-155 levels and CK19 mRNA levels in station 8 nodes were variable and did not correlate with RFS or OS. We conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Nguyen, H. V., Gore, J., Zhong, X., Savant, S. S., Deitz-McElyea, S., Schmidt, C. M., … Korc, M. (2016). MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 20(10), 1699–1706. https://doi.org/10.1007/s11605-016-3208-x | en_US |
dc.identifier.issn | 1091-255X | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/15530 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | 10.1007/s11605-016-3208-x | en_US |
dc.relation.journal | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Lymph node | en_US |
dc.subject | MicroRNA | en_US |
dc.subject | Pancreatic cancer | en_US |
dc.title | MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection | en_US |
dc.type | Article | en_US |