APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba

dc.contributor.authorHendrie, Hugh C.
dc.contributor.authorMurrell, Jill
dc.contributor.authorBaiyewu, Olusegun
dc.contributor.authorLane, Kathleen A.
dc.contributor.authorPurnell, Christianna
dc.contributor.authorOgunniyi, Adesola
dc.contributor.authorUnverzagt, Frederick W.
dc.contributor.authorHall, Kathleen
dc.contributor.authorCallahan, Christopher M.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorGureje, Oye
dc.contributor.authorHake, Ann
dc.contributor.authorForoud, Tatiana
dc.contributor.authorGao, Sujuan
dc.contributor.departmentDepartment of Psychiatry, IU School of Medicineen_US
dc.date.accessioned2016-03-03T15:54:47Z
dc.date.available2016-03-03T15:54:47Z
dc.date.issued2014-06
dc.description.abstractBackground There is little information on the association of the APOEe4 allele and AD risk in African populations. In previous analyses from the Indianapolis-Ibadan dementia project, we have reported that APOE ε4 increased the risk for Alzheimer’s disease (AD) in African Americans but not in Yoruba. This study represents a replication of this earlier work using enriched cohorts and extending the analysis to include cognitive decline. Methods In this longitudinal study of two community dwelling cohorts of elderly Yoruba and African Americans, APOE genotyping was conducted from blood samples taken on or before 2001 (1,871 African Americans & 2,200 Yoruba). Mean follow up time was 8.5 years for African Americans and 8.8 years for Yoruba. The effects of heterozygosity or homozygosity of ε4 and of the possession of e4 on time to incident AD and on cognitive decline were determined using Cox’s proportional hazards regression and mixed effects models. Results After adjusting for covariates, one or two copies of the APOE ε4 allele were significant risk factors for incident AD (p < 0.0001) and cognitive decline in the African-American population (p < 0001). In the Yoruba, only homozygosity for APOE ε4 was a significant risk factor for AD (p = 0.0002) but not for cognitive decline (p = 0.2346), however, possession of an e4 allele was significant for both incident AD (p = 0.0489) and cognitive decline (p = 0.0425). Conclusions In this large longitudinal comparative study, APOE ε4 had a significant, but weaker, effect on incident AD and on cognitive decline in Yoruba than in African Americans. The reasons for these differences remain unclear.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationHendrie, H. C., Murrell, J., Baiyewu, O., Lane, K. A., Purnell, C., Ogunniyi, A., … Gao, S. (2014). APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba. International Psychogeriatrics / IPA, 26(6), 977–985. http://doi.org/10.1017/S1041610214000167en_US
dc.identifier.issn1041-6102en_US
dc.identifier.urihttps://hdl.handle.net/1805/8664
dc.language.isoen_USen_US
dc.publisherCambridge University Pressen_US
dc.relation.isversionof10.1017/S1041610214000167en_US
dc.relation.journalInternational psychogeriatrics / IPAen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectcognitive impairmenten_US
dc.subjectAPOE ε4en_US
dc.subjectAfrican Americansen_US
dc.subjectYorubaen_US
dc.titleAPOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yorubaen_US
dc.typeArticleen_US
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