Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3
dc.contributor.author | Tachó-Piñot, Roser | |
dc.contributor.author | Stamper, Christopher T. | |
dc.contributor.author | King, James I. | |
dc.contributor.author | Matei-Rascu, Veronika | |
dc.contributor.author | Richardson, Erin | |
dc.contributor.author | Li, Zhi | |
dc.contributor.author | Roberts, Luke B. | |
dc.contributor.author | Bassett, John W. | |
dc.contributor.author | Melo-Gonzalez, Felipe | |
dc.contributor.author | Fiancette, Rémi | |
dc.contributor.author | Lin, I-Hsuan | |
dc.contributor.author | Dent, Alexander | |
dc.contributor.author | Harada, Yohsuke | |
dc.contributor.author | Finlay, Conor | |
dc.contributor.author | Mjösberg, Jenny | |
dc.contributor.author | Withers, David R. | |
dc.contributor.author | Hepworth, Matthew R. | |
dc.contributor.department | Microbiology and Immunology, School of Medicine | |
dc.date.accessioned | 2024-06-13T13:46:33Z | |
dc.date.available | 2024-06-13T13:46:33Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Innate lymphoid cells (ILCs) are tissue-resident effector cells with roles in tissue homeostasis, protective immunity, and inflammatory disease. Group 3 ILCs (ILC3s) are classically defined by the master transcription factor RORγt. However, ILC3 can be further subdivided into subsets that share type 3 effector modules that exhibit significant ontological, transcriptional, phenotypic, and functional heterogeneity. Notably lymphoid tissue inducer (LTi)-like ILC3s mediate effector functions not typically associated with other RORγt-expressing lymphocytes, suggesting that additional transcription factors contribute to dictate ILC3 subset phenotypes. Here, we identify Bcl6 as a subset-defining transcription factor of LTi-like ILC3s in mice and humans. Deletion of Bcl6 results in dysregulation of the LTi-like ILC3 transcriptional program and markedly enhances expression of interleukin-17A (IL-17A) and IL-17F in LTi-like ILC3s in a manner in part dependent upon the commensal microbiota-and associated with worsened inflammation in a model of colitis. Together, these findings redefine our understanding of ILC3 subset biology. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Tachó-Piñot R, Stamper CT, King JI, et al. Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3. Cell Rep. 2023;42(11):113425. doi:10.1016/j.celrep.2023.113425 | |
dc.identifier.uri | https://hdl.handle.net/1805/41526 | |
dc.language.iso | en_US | |
dc.publisher | Cell Press | |
dc.relation.isversionof | 10.1016/j.celrep.2023.113425 | |
dc.relation.journal | Cell Reports | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Bcl6 | |
dc.subject | Immunology | |
dc.subject | IL-17 | |
dc.subject | ILC3 | |
dc.subject | Innate lymphoid cells | |
dc.subject | Intestinal immunity | |
dc.subject | Lymphoid tissue inducer | |
dc.subject | Microbiota | |
dc.subject | Transcription factor | |
dc.title | Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3 | |
dc.type | Article |