Structural Modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that Improve Selectivity for the Inhibition of Melanoma Cells Containing Active ERK Signaling

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dc.contributor.authorJung, Kwan-Young
dc.contributor.authorSamadani, Ramin
dc.contributor.authorChauhan, Jay
dc.contributor.authorNevels, Kerrick
dc.contributor.authorYap, Jeremy L.
dc.contributor.authorZhang, Jun
dc.contributor.authorWorlikar, Shilpa
dc.contributor.authorLanning, Maryanna E.
dc.contributor.authorChen, Lijia
dc.contributor.authorEnsey, Mary
dc.contributor.authorShukla, Sagar
dc.contributor.authorSalmo, Rosene
dc.contributor.authorHeinzl, Geoffrey
dc.contributor.authorGordon, Caryn
dc.contributor.authorDukes, Troy
dc.contributor.authorMacKerell, Alexander D., Jr.
dc.contributor.authorShapiro, Paul
dc.contributor.authorFletcher, Steven
dc.contributor.departmentPharmacology and Toxicology, School of Medicine
dc.date.accessioned2025-05-09T12:03:57Z
dc.date.available2025-05-09T12:03:57Z
dc.date.issued2013
dc.description.abstractWe herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationJung KY, Samadani R, Chauhan J, et al. Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling. Org Biomol Chem. 2013;11(22):3706-3732. doi:10.1039/c3ob40199e
dc.identifier.urihttps://hdl.handle.net/1805/47925
dc.language.isoen_US
dc.publisherRoyal Society of Chemistry
dc.relation.isversionof10.1039/c3ob40199e
dc.relation.journalOrganic & Biomolecular Chemistry
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAntineoplastic agents
dc.subjectMelanoma
dc.subjectThiazolidinediones
dc.titleStructural Modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that Improve Selectivity for the Inhibition of Melanoma Cells Containing Active ERK Signaling
dc.typeArticle
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