Association of erythrocyte n-3 polyunsaturated fatty acids with incident type 2 diabetes in a Chinese population
dc.contributor.author | Zheng, Ju-Sheng | |
dc.contributor.author | Lin, Jie-sheng | |
dc.contributor.author | Dong, Hong-li | |
dc.contributor.author | Zeng, Fang-fang | |
dc.contributor.author | Li, Duo | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Chen, Yu-ming | |
dc.contributor.department | Epidemiology, School of Public Health | en_US |
dc.date.accessioned | 2019-01-28T20:43:27Z | |
dc.date.available | 2019-01-28T20:43:27Z | |
dc.date.issued | 2018-09-26 | |
dc.description.abstract | Summary Background & aims The association between circulating n-3 polyunsaturated fatty acid (PUFA) biomarkers and incident type 2 diabetes in Asian populations remains unclear. We aimed to examine the association of erythrocyte n-3 PUFA with incident type 2 diabetes in a Chinese population. Methods A total of 2671 participants, aged 40–75 y, free of type 2 diabetes at baseline, were included in the present analysis. Incident type 2 diabetes cases (n = 213) were ascertained during median follow-up of 5.6 years. Baseline erythrocyte fatty acids were measured by gas chromatography. We used multivariable Cox regression models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of type 2 diabetes across quartiles of erythrocyte n-3 PUFA. Results After adjustment for potential confounders, HRs (95% CIs) of type 2 diabetes were 0.68 (0.47, 1.00), 0.77 (0.52, 1.15), and 0.63 (0.41, 0.95) in quartiles 2–4 of docosapentaenoic acid (C22:5n-3) (P-trend = 0.07), compared with quartile 1; and 1.08 (0.74, 1.60), 1.03 (0.70, 1.51), and 0.57 (0.38, 0.86) for eicosapentaenoic acid (C20:5n-3) (P-trend = 0.007). No association was found for docosahexaenoic acid (C22:6n-3) or alpha-linolenic acid (C18:3n-3). Conclusions Erythrocyte n-3 PUFA from marine sources (C22:5n-3 and C20:5n-3), as biomarkers of dietary marine n-3 PUFA, were inversely associated with incident type 2 diabetes in this Chinese population. Future prospective investigations in other Asian populations are necessary to confirm our findings. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Zheng, J.-S., Lin, J., Dong, H., Zeng, F., Li, D., Song, Y., & Chen, Y. (2018). Association of erythrocyte n-3 polyunsaturated fatty acids with incident type 2 diabetes in a Chinese population. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2018.09.018 | en_US |
dc.identifier.issn | 0261-5614 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/18261 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.clnu.2018.09.018 | en_US |
dc.relation.journal | Clinical Nutrition | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.source | Publisher | en_US |
dc.subject | Erythrocyte | en_US |
dc.subject | Fatty acids | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.subject | Prospective association | en_US |
dc.subject | Cohort study | en_US |
dc.title | Association of erythrocyte n-3 polyunsaturated fatty acids with incident type 2 diabetes in a Chinese population | en_US |
dc.type | Article | en_US |
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